Calorie restriction extends yeast life span by lowering the level of NADH

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Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

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Insights into Cellular Stress Revealed by SIRT7

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Specially regulated electron deprivation extremely prolongs lifespan and delays aging in middle-aged rotifers

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Cardiac Remodeling Under Hyperoxic Conditions

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Faculty Opinions recommendation of Mitochondrial function as a determinant of life span.

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Additional file 1 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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Additional file 3 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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Additional file 2 of NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

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The deacetylase Sir2 is the primary sensor driving transcriptional changes in response to low NAD+ in the yeast Kluyveromyces lactis

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Silent chromatin dynamics upon major metabolic transitions

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Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice.

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Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats

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Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats

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BindingDB Entry 50026905: Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

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Establishing a role for specific nutrients in Drosophila dietary restriction

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Aging and Dietary Restriction: The Yeast Paradigm

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Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

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Effects of Physiologic, Metabolic and Molecular Adaptations to Calorie Restriction on Biomarkers of Longevity

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Diet and Nutrition to Prevent and Treat Cardiovascular Diseases

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Acetylation in the Control of Mitochondrial Metabolism and Integrity

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Making Yeast Live Longer

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Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

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Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

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