The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Open accessAbstract
We are witnessing a period of renewed interest in the biology of the mitochondrion. The mitochondrion serves a critical function in the maintenance of cellular energy stores, thermogenesis, and apoptosis. Moreover, alterations in mitochondrial function contribute to several inherited and acquired human diseases and the aging process. This review summarizes our understanding of the transcriptional regulatory mechanisms involved in the biogenesis and energy metabolic function of mitochondria in higher organisms.
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“It is well established that the biogenesis of normal, functional mitochondria requires the activation of a number of transcription factors in addition to PPARδ (22–24).”
From High-fat diets cause insulin resistance despite an increase in muscle mitochondria (2008) · cites this paper as [22]
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“The coordinated increase in transcription of genes encoding mitochondrial proteins is mediated by the transcription coactivator PGC-1α, which activates the NRFs, ERRs, PPARs, and MEFs and, thus, plays the key role in mediating adaptive mitochondrial biogenesis (22–24).”
From High-fat diets cause insulin resistance despite an increase in muscle mitochondria (2008) · cites this paper as [22]
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“Chronic exposure to relatively high levels of NO results in mitochondrial biogenesis [113-115], which could reprogram a cell or tissue to have a higher metabolic capacity.”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [113]
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Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
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Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
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Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243
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Kemper, M. F., Stirone, C., Krause, D. N., Duckles, S. P., & Procaccio, V. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.009 · Cited by 42
Kemper, M. F., Zhao, Y., Duckles, S. P., & Krause, D. N. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.159 · Cited by 38
Chamma, C. M. D. O., Bargut, T. C. L., Mandarim-de-Lacerda, C. A., & Aguila, M. B. (2017) · Food & Function · doi:10.1039/c6fo01663d · Cited by 27
Zhou, H., Yuan, D., Gao, W., Tian, J., Sun, H., Yu, S., Wang, J., & Sun, L. (2020) · IUBMB Life · doi:10.1002/iub.2289 · Cited by 22
Araujo, H. N., Lima, T. I., Guimarães, D. S. P. S. F., Oliveira, A. G., Favero-Santos, B. C., Branco, R. C. S., da Silva Araújo, R. M., Dantas, A. F. B., Castro, A., Chacon-Mikahil, M. P. T., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00233.2020 · Cited by 17
Shakova, F. M., Kirova, Y. I., Silachev, D. N., Romanova, G. A., & Morozov, S. G. (2021) · Brain Sciences · doi:10.3390/brainsci11030325 · Cited by 13
“Bilateral focal ischemic stroke was modeled in the rat prefrontal cortex (fields Fr1 and Fr2) by photochemically induced vascular thrombosis (PT) (Figure 2A) [62,63].”
MethodProteomic aging signatures across mouse organs and life stages
Scifo, E., Morsy, S., Liu, T., Xie, K., Schaaf, K., Bano, D., & Ehninger, D. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00509-x · Cited by 10
“This decline coincided with reductions in TFAM (mitochondrial biogenesis) (Kelly and Scarpulla, 2004), SOD2 (antioxidant defense) (Cramer-Morales et al, 2015), and PARK7 (mitochondrial protection) (Irrcher et al, 2010), suggesting a transient phase of mitochondrial vulnerability (Dataset EV4).”
Metadata
- Authors
- Kelly, D. P., & Scarpulla, R. C.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Kelly, Daniel P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-02-15
- Volume
- 18
- Issue
- 4
- Pages
- 357-368
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2113515610
- Cited by
- 1,243
- References
- 108
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 31 · 2023: 50 · 2022: 53 · 2021: 53 · 2020: 47 · 2019: 67 · 2018: 53 · 2017: 63 · 2016: 67 · 2015: 62 · 2014: 65 · 2013: 64 · 2012: 84
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50hl061006-05, HL57278)
- U.S. Public Health Service
- National Heart, Lung, and Blood Institute (P01HL057278, HL58493, HL57278, R01HL058493, HL-61006)
- National Institute of General Medical Sciences (GM32525)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 45416)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial biogenesis, mitochondrial function, transcriptional regulation, transcriptional regulatory networks, mitochondrial bioenergetics, thermogenesis, apoptosis, mitochondrial disease, aging
- MeSH terms
- Animals, Cell Nucleus, DNA, Mitochondrial, Enzymes, Gene Expression Regulation, Humans, Mitochondria, Transcription, Genetic, Vertebrates, Genome
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