Kelly, Daniel P.

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 1,285

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 1,243

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 1,195

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,020

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 951

A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsMetabolism and Genetic Disorders

Cited by 943

Transcriptional integration of mitochondrial biogenesis

Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 798

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 663

A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsCardiovascular Function and Risk Factors

Cited by 501

Mitochondrial biogenesis and dynamics in the developing and diseased heart

Dorn, G. W., Vega, R. B., & Kelly, D. P. (2015) · Genes & Development

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 470

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsParaoxonase enzyme and polymorphisms

Cited by 410

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Russell, L. K., Mansfield, C. M., Lehman, J. J., Kovacs, A., Courtois, M., Saffitz, J. E., Medeiros, D. M., Valencik, M. L., McDonald, J. A., & Kelly, D. P. (2004) · Circulation Research

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 402

PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism

Wende, A. R., Huss, J. M., Schaeffer, P. J., Giguère, V., & Kelly, D. P. (2005) · Molecular and Cellular Biology

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 354

Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart

Lai, L., Leone, T. C., Zechner, C., Schaeffer, P. J., Kelly, S. M., Flanagan, D. P., Medeiros, D. M., Kovacs, A., & Kelly, D. P. (2008) · Genes & Development

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 326

Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity

Zechner, C., Lai, L., Zechner, J. F., Geng, T., Yan, Z., Rumsey, J. W., Collia, D., Chen, Z., Wozniak, D. F., Leone, T. C., et al. (2010) · Cell Metabolism

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 274

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

Cited by 270

p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α

Barger, P. M., Browning, A. C., Garner, A. N., & Kelly, D. P. (2001) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 260

A role for the transcriptional coactivator PGC-1α in muscle refueling.

Wende, A. R., Schaeffer, P. J., Parker, G. J., Zechner, C., Han, D.-H., Chen, M. M., Hancock, C. R., Lehman, J. J., Huss, J. M., McClain, D. A., et al. (2007) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 257

Transcriptional Activation Of Energy Metabolic Switches In The Developing And Hypertrophied Heart

Lehman, J. J., & Kelly, D. P. (2002) · Clinical and Experimental Pharmacology and Physiology

Peroxisome Proliferator-Activated ReceptorsMitochondrial Function and Pathology

Cited by 257

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

Yang, J., Sambandam, N., Han, X., Gross, R. W., Courtois, M., Kovacs, A., Febbraio, M., Finck, B. N., & Kelly, D. P. (2007) · Circulation Research

Peroxisome Proliferator-Activated ReceptorsCardiovascular Function and Risk Factors

Cited by 246

Peroxisome Proliferator-activated Receptor α (PPARα) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart

Finck, B. N., & Kelly, D. P. (2002) · Journal of Molecular and Cellular Cardiology

Peroxisome Proliferator-Activated ReceptorsCardiovascular Function and Risk Factors

Cited by 160

The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

Lehman, J. J., Boudina, S., Banke, N. H., Sambandam, N., Han, X., Young, D. M., Leone, T. C., Gross, R. W., Lewandowski, E. D., Abel, E. D., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 158

Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

Luda, K. M., Longo, J., Kitchen-Goosen, S. M., Duimstra, L. R., Ma, E. H., Watson, M. J., Oswald, B. M., Fu, Z., Madaj, Z., Kupai, A., et al. (2023) · Immunity

T-cell and B-cell ImmunologyDiet and metabolism studies

Cited by 140

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2

Gan, Z., Burkart-Hartman, E. M., Han, D.-H., Finck, B., Leone, T. C., Smith, E. Y., Ayala, J. E., Holloszy, J., & Kelly, D. P. (2011) · Genes & Development

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

Cited by 138