Cited by 1,243Mitochondrial Function and PathologyAdipose Tissue and MetabolismAutophagy in Disease and Therapy

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

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Kelly, Daniel P., Scarpulla, Richard C.·2004·Genes & Development

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Abstract

We are witnessing a period of renewed interest in the biology of the mitochondrion. The mitochondrion serves a critical function in the maintenance of cellular energy stores, thermogenesis, and apoptosis. Moreover, alterations in mitochondrial function contribute to several inherited and acquired human diseases and the aging process. This review summarizes our understanding of the transcriptional regulatory mechanisms involved in the biogenesis and energy metabolic function of mitochondria in higher organisms.

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“All of these transcription factors directly regulate the expression of certain nuclear-encoded mitochondrial genes and were discussed in greater detail in two recent reviews (Kelly and Scarpulla, 2004; Puigserver and Spiegelman, 2003).”
Background
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See all 1,243

Authors: Kelly, D. P., & Scarpulla, R. C.
Affiliations: Washington University in St. Louis (US)
ORCID: Kelly, Daniel P.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2004-02-15
Volume: 18
Issue: 4
Pages: 357-368
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1177604
OpenAlex: W2113515610
Cited by: 1,243
References: 108
Citations by year: 2026: 21 · 2025: 21 · 2024: 31 · 2023: 50 · 2022: 53 · 2021: 53 · 2020: 47 · 2019: 67 · 2018: 53 · 2017: 63 · 2016: 67 · 2015: 62 · 2014: 65 · 2013: 64 · 2012: 84
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl061006-05, HL57278)
U.S. Public Health Service
National Heart, Lung, and Blood Institute (P01HL057278, HL58493, HL57278, R01HL058493, HL-61006)
National Institute of General Medical Sciences (GM32525)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 45416)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial biogenesis, mitochondrial function, transcriptional regulation, transcriptional regulatory networks, mitochondrial bioenergetics, thermogenesis, apoptosis, mitochondrial disease, aging
MeSH terms: Animals, Cell Nucleus, DNA, Mitochondrial, Enzymes, Gene Expression Regulation, Humans, Mitochondria, Transcription, Genetic, Vertebrates, Genome

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

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