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Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling
Open accessAbstract
Desensitization of activated receptors is an important mechanism for terminating signal transduction. Here we show that phytochrome (phy) A, a predominant photoreceptor for seedling deetiolation, colocalizes in nuclear bodies with CONSTITUTIVELY PHOTOMORPHOGENIC (COP) 1, a RING motif-containing E3 ligase. The phyA PAS domain interacts with the COP1 WD40 domain. Both the Pr and the Pfr forms of phyA, as well as the PHYA apoprotein, are ubiquitinated by COP1 in vitro. The phyA destruction rate is decreased in cop1 mutants and by expression of a COP1 RING motif mutant. Our results indicate that COP1 acts as an E3 ligase to regulate phyA signaling by targeting elimination of the phyA photoreceptor itself.
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Citations
Cited by
Photoreceptor Signaling Networks in Plant Responses to Shade
Casal, J. J. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120221 · Cited by 865
Phytochrome Signaling Mechanisms
Li, J., Li, G., Wang, H., & Wang Deng, X. (2011) · The Arabidopsis Book · doi:10.1199/tab.0148 · Cited by 561
Decoding of Light Signals by Plant Phytochromes and Their Interacting Proteins
Bae, G., & Choi, G. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092859 · Cited by 490
Phytochrome signaling mechanisms and the control of plant development
Chen, M., & Chory, J. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.002 · Cited by 448
The Aspergillus nidulans Phytochrome FphA Represses Sexual Development in Red Light
Blumenstein, A., Vienken, K., Tasler, R., Purschwitz, J., Veith, D., Frankenberg-Dinkel, N., & Fischer, R. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.061 · Cited by 357
Metadata
- Authors
- Seo, H. S., Watanabe, E., Tokutomi, S., Nagatani, A., & Chua, N.-H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-03-15
- Volume
- 18
- Issue
- 6
- Pages
- 617-622
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2133307159
- Cited by
- 324
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Seo, H. S., Watanabe, E., Tokutomi, S., Nagatani, A., & Chua, N.-H. (2004). Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling. Genes & Development. https://doi.org/10.1101/gad.1187804
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