The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Myc activates telomerase
Open accessAbstract
Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neoplastic transformation have remained a mystery. Here, we show that Myc induces telomerase in both normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts. Myc increases expression of hEST2 (hTRT/TP2), the limiting subunit of telomerase, and both Myc and hEST2 can extend the life span of HMECs. The ability of Myc to activate telomerase may contribute to its ability to promote tumor formation.
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Citations
Cites
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Cited by
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
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Human Telomerase and Its Regulation
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Direct activation of TERT transcription by c-MYC
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Metadata
- Authors
- Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-06-15
- Volume
- 12
- Issue
- 12
- Pages
- 1769-1774
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2141704910
- Cited by
- 653
- References
- 15
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Myc activates telomerase. https://app.cochat.ai/papers/10.1101/gad.12.12.1769
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- Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998). Myc activates telomerase. Genes & Development. https://doi.org/10.1101/gad.12.12.1769
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
