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Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexes
Open accessAbstract
We show that the Saccharomyces cerevisiae recombination protein Rad52 and the single-strand DNA-binding protein RPA assemble into cytologically detectable subnuclear complexes (foci) during meiotic recombination. Immunostaining shows extensive colocalization of Rad52 and RPA and more limited colocalization of Rad52 with the strand exchange protein Rad51. Rad52 and RPA foci are distinct from those formed by Rad51, and its meiosis-specific relative Dmc1, in that they are also detected in meiosis during replication. In addition, RPA foci are observed during mitotic S phase. Double-strand breaks (DSBs) promote formation of RPA, Rad52, and Rad51 foci. Mutants that lack Spo11, a protein required for DSB formation, are defective in focus formation, and this defect is suppressed by ionizing radiation in a dose-dependent manner. DSBs are not sufficient for the appearance of Rad51 foci; Rad52, Rad55, and Rad57 are also required supporting a model in which these three proteins promote meiotic recombination by promoting the assembly of strand exchange complexes.
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Cites
Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540
Prakash, L. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00352525 · Cited by 291
Cited by
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Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Meiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,255
Choreography of the DNA Damage Response
Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891
Hunter, N., & Kleckner, N. (2001) · Cell · doi:10.1016/s0092-8674(01)00430-5 · Cited by 658
Dasika, G. K., Lin, S.-C. J., Zhao, S., Sung, P., Tomkinson, A., & Lee, E. Y.-H. P. (1999) · Oncogene · doi:10.1038/sj.onc.1203283 · Cited by 427
Metadata
- Authors
- Gasior, S. L., Wong, A. K., Kora, Y., Shinohara, A., & Bishop, D. K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-07-15
- Volume
- 12
- Issue
- 14
- Pages
- 2208-2221
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2113227424
- Cited by
- 262
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Gasior, S. L., Wong, A. K., Kora, Y., Shinohara, A., & Bishop, D. K. (1998). Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexes. Genes & Development. https://doi.org/10.1101/gad.12.14.2208
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