DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

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Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

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Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

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Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

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The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

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Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

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Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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A role for ATR in the DNA damage-induced phosphorylation of p53

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

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The DNA-dependent protein kinasePreprint

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Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.Preprint

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Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

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Abnormal Centrosome Amplification in the Absence of p53

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

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A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

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Meiotic Prophase Arrest with Failure of Chromosome Synapsis in Mice Deficient for Dmc1 , a Germline-Specific RecA Homolog

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Involvement of Brca2 in DNA Repair

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Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

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Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

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DNA end-joining: from yeast to man

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

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The Mouse RecA-like Gene Dmc1 Is Required for Homologous Chromosome Synapsis during Meiosis

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Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

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RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

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XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double‐strand break repair and serves as a barrier to error‐prone DNA repair pathways.

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hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

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Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

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Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

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Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

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The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

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Yeast Ku as a Regulator of Chromosomal DNA End Structure

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Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

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Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

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A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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The Many Interfaces of Mre11

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

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Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

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MDM2 suppresses p73 function without promoting p73 degradation

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Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

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Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

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Ku80 is required for immunoglobulin isotype switching

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Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

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Interaction of DNA‐dependent protein kinase with DNA and with Ku: biochemical and atomic‐force microscopy studies

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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.Preprint

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ATM: from gene to function

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Binding of double-strand breaks in DNA by human Rad52 protein

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Replication Checkpoint Enforced by Kinases Cds1 and Chk1

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

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Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching

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Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double‐strand breaks

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DNA end-joining catalyzed by human cell-free extracts

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The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

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Rad52 forms ring structures and co‐operates with RPA in single‐strand DNA annealing

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Brca2 is required for embryonic cellular proliferation in the mouse.Preprint

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Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

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Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

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Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I

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Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexesPreprint

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DNA looping by Ku and the DNA-dependent protein kinase

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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

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Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.Preprint

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Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

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Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1Preprint

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Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

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Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2

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The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA

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BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

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Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

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