The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
Open accessAbstract
Intercellular communication is needed for both the generation of the mesodermal germ layer and its division into distinct subpopulations. To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during later embryonic development, we have introduced specific mutations into the Fgfr1 locus by gene targeting. Our results show functional dominance of one of the receptor isoforms and suggest a function for the autophosphorylation of site Y766 in the negative regulation of FGFR1 activity. Y766F and hypomorphic mutations in Fgfr1 generate opposite phenotypes in terms of homeotic vertebral transformations, suggesting a role for FGFR1 in patterning the embryonic anteriorposterior axis by way of regulation of Hox gene activity.
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Citations
Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Self-citationReceptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Cited by
Dubrulle, J., McGrew, M. J., & Pourquié, O. (2001) · Cell · doi:10.1016/s0092-8674(01)00437-8 · Cited by 667
Signaling and transcriptional regulation in osteoblast commitment and differentiation
Huang, W. (2007) · Frontiers in Bioscience · doi:10.2741/2296 · Cited by 649
Fibroblast Growth Factor Signaling during Early Vertebrate Development
Böttcher, R. T., & Niehrs, C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0040 · Cited by 540
Morriss‐Kay, G. M., & Wilkie, A. O. M. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00475.x · Cited by 483
Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis
Tzouanacou, E., Wegener, A., Wymeersch, F. J., Wilson, V., & Nicolas, J.-F. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.002 · Cited by 425
Metadata
- Authors
- Partanen, J., Schwartz, L., & Rossant, J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-08-01
- Volume
- 12
- Issue
- 15
- Pages
- 2332-2344
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2136570112
- Cited by
- 224
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. https://app.cochat.ai/papers/10.1101/gad.12.15.2332
- The paper
- Partanen, J., Schwartz, L., & Rossant, J. (1998). Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes & Development. https://doi.org/10.1101/gad.12.15.2332
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