Fibroblast Growth Factor Signaling during Early Vertebrate Development
Abstract
Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.
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Mutations in the tyrosine kinase domain of FGFR-1 are predicted to decrease or inhibit kinase activity by disrupting receptor conformation and/or altering the normal pattern of phosphorylation.
“Mutations in the tyrosine kinase domain of FGFR-1 are predicted to decrease or inhibit kinase activity by disrupting receptor conformation (Ile538Val, Asn724Lys, and Gly703Arg) and/or altering the normal pattern of phosphorylation of the kinase domain (Ala520Thr, Gly703Ser, Pro722Ser, Pro745Ser, and Pro772Ser).”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [17]
FGFR-1 signaling through the mitogen-activated protein kinase pathway regulates neuronal migration, differentiation, survival, and cell proliferation during embryonic development.
“FGFR-1 signaling through this pathway regulates neuronal migration, differentiation, and survival, as well as cell proliferation during embryonic development.”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [17]
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Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390 · see citing works
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- Authors
- Böttcher, R. T., & Niehrs, C.
- Affiliations
- Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany
- German Cancer Research Center (DE)
- ORCID
- Niehrs, Christof
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-10-26
- Volume
- 26
- Issue
- 1
- Pages
- 63-77
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2168583421
- Cited by
- 540
- References
- 222
- Citations by year
- 2025: 9 · 2024: 9 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 24 · 2019: 10 · 2018: 30 · 2017: 16 · 2016: 25 · 2015: 27 · 2014: 29 · 2013: 47 · 2012: 36
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- FGF signaling, early embryonic development, germ layer induction, germ layer patterning, morphogenetic movements, cell migration, cell differentiation, cell proliferation, apoptosis, cell adhesion, chemotaxis, vertebrate development
- MeSH terms
- Animals, Chemotaxis, Endoderm, Fibroblast Growth Factors, Gastrula, Homeostasis, Humans, Mesoderm, Morphogenesis, Protein-Tyrosine Kinases, Signal Transduction, Receptors, Fibroblast Growth Factor, Embryonic Development
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