Cited by 540Fibroblast Growth Factor ResearchDevelopmental Biology and Gene RegulationPluripotent Stem Cells Research

Fibroblast Growth Factor Signaling during Early Vertebrate Development

Böttcher, Ralph T., Niehrs, Christof·2005·Endocrine Reviews

Abstract

Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.

Integrity signals

Registry

Crossref · 10.1210/er.2003-0040

Cites

222 of 222 references verified0 citation errors · 0 not checkable

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  • Mutations in the tyrosine kinase domain of FGFR-1 are predicted to decrease or inhibit kinase activity by disrupting receptor conformation and/or altering the normal pattern of phosphorylation.

    “Mutations in the tyrosine kinase domain of FGFR-1 are predicted to decrease or inhibit kinase activity by disrupting receptor conformation (Ile538Val, Asn724Lys, and Gly703Arg) and/or altering the normal pattern of phosphorylation of the kinase domain (Ala520Thr, Gly703Ser, Pro722Ser, Pro745Ser, and Pro772Ser).”
  • FGFR-1 signaling through the mitogen-activated protein kinase pathway regulates neuronal migration, differentiation, survival, and cell proliferation during embryonic development.

    “FGFR-1 signaling through this pathway regulates neuronal migration, differentiation, and survival, as well as cell proliferation during embryonic development.”

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Authors
Böttcher, R. T., & Niehrs, C.
Affiliations
  • Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany
  • German Cancer Research Center (DE)
Venue
Endocrine Reviews
Published
2004-10-26
Volume
26
Issue
1
Pages
63-77
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W2168583421
Cited by
540
References
222
Citations by year
2025: 9 · 2024: 9 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 24 · 2019: 10 · 2018: 30 · 2017: 16 · 2016: 25 · 2015: 27 · 2014: 29 · 2013: 47 · 2012: 36
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
FGF signaling, early embryonic development, germ layer induction, germ layer patterning, morphogenetic movements, cell migration, cell differentiation, cell proliferation, apoptosis, cell adhesion, chemotaxis, vertebrate development
MeSH terms
Animals, Chemotaxis, Endoderm, Fibroblast Growth Factors, Gastrula, Homeostasis, Humans, Mesoderm, Morphogenesis, Protein-Tyrosine Kinases, Signal Transduction, Receptors, Fibroblast Growth Factor, Embryonic Development

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