The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Open accessAbstract
INK4 and CIP/KIP are two distinct families of cyclin-dependent kinase (CDK) inhibitors implicated in mediating a wide range of cell growth control signals. We have created p18 INK4c-deficient mice. These mice develop gigantism and widespread organomegaly. The pituitary gland, spleen, and thymus are disproportionately enlarged and hyperplastic. T and B lymphocytes develop normally in p18-deficient mice, but both exhibit increased cellularity and a higher proliferative rate upon mitogenic stimulation. Loss of p18, like that of p27, but not other CDK inhibitor genes, leads to a gradual progression from intermediate lobe pituitary hyperplasia in young mice to an adenoma by 10 months of age with a nearly complete penetrance. Mice lacking both p18 and p27, like mice chimeric for Rb deficiency, invariably died from pituitary adenomas by 3 months. Hence, p18 and p27 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis, likely by controlling the function of Rb.
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Cited by
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
Yokoyama, A., & Cleary, M. L. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.003 · Cited by 555
p27Kip1 links cell proliferation to morphogenesis in the developing organ of Corti
Chen, P., & Segil, N. (1999) · Development · doi:10.1242/dev.126.8.1581 · Cited by 555
The pathogenesis of pituitary tumours
Asa, S. L., & Ezzat, S. (2002) · Nature Reviews Cancer · doi:10.1038/nrc926 · Cited by 435
Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity
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Self-citation
Metadata
- Authors
- Franklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., & Xiong, Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-09-15
- Volume
- 12
- Issue
- 18
- Pages
- 2899-2911
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W4298304887
- Cited by
- 412
- References
- 36
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. https://app.cochat.ai/papers/10.1101/gad.12.18.2899
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- Franklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., & Xiong, Y. (1998). CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes & Development. https://doi.org/10.1101/gad.12.18.2899
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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