The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
Open accessAbstract
Summary Menin displays the unique ability to either promote oncogenic function in the hematopoietic lineage or suppress tumorigenesis in the endocrine lineage, however its molecular mechanism of action has not been defined. We demonstrate here that these discordant functions are unified by menin's ability to serve as a molecular adaptor that physically links the MLL histone methyltransferase with LEDGF, a chromatin-associated protein previously implicated in leukemia, auto-immunity and HIV-1 pathogenesis. LEDGF is required for both MLL-dependent transcription and leukemic transformation. Conversely, a subset of menin mutations in MEN1 patients abrogates interaction with LEDGF while preserving MLL interaction, but nevertheless compromises MLL/menin-dependent functions. Thus, LEDGF critically associates with MLL and menin at the nexus of transcriptional pathways that are recurrently targeted in diverse diseases.
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Metadata
- Authors
- Yokoyama, A., & Cleary, M. L.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 14
- Issue
- 1
- Pages
- 36-46
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2094799740
- Cited by
- 555
- References
- 61
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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