The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
Open accessAbstract
RAD53 and MEC1 are essential genes required for the transcriptional and cell cycle responses to DNA damage and DNA replication blocks. We have examined the essential function of these genes and found that their lethality but not their checkpoint defects can be suppressed by increased expression of genes encoding ribonucleotide reductase. Analysis of viable null alleles revealed that Mec1 plays a greater role in response to inhibition of DNA synthesis than Rad53. The loss of survival in mec1 and rad53 null or point mutants in response to transient inhibition of DNA synthesis is not a result of inappropriate anaphase entry but primarily to an inability to complete chromosome replication. We propose that this checkpoint pathway plays an important role in the maintenance of DNA synthetic capabilities when DNA replication is stressed.
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Cites
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · cited 1×
“ATM controls the timely activation of p53, a transcription factor that activates transcription of the cdk inhibitor p21 (Kastan et al. 1992).”
BackgroundSanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320
Self-citationRegulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science · doi:10.1126/science.271.5247.357 · Cited by 585 · cited 4×
“Because RAD53 and MEC1 operate in the same checkpoint pathway (Sanchez et al. 1996; Sun et al. 1996), it is possible that they are essential for the same reason.”
BackgroundInfluentialSelf-citationMorrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90480-8 · Cited by 370
Sun, Z., Fay, D. S., Marini, F., Foiani, M., & Stern, D. F. (1996) · Genes & Development · doi:10.1101/gad.10.4.395 · Cited by 300
Cited by
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Self-citationATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985
Self-citationChoreography of the DNA Damage Response
Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891
Gasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.2987 · Cited by 542
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Metadata
- Authors
- Desany, B. A., Alcasabas, A. A., Bachant, J. B., & Elledge, S. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-09-15
- Volume
- 12
- Issue
- 18
- Pages
- 2956-2970
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2050189514
- Cited by
- 455
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Desany, B. A., Alcasabas, A. A., Bachant, J. B., & Elledge, S. J. (1998). Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes & Development. https://doi.org/10.1101/gad.12.18.2956
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
