The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
Open accessAbstract
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired(upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.
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Cites
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Cited by
The JAK/STAT signaling pathway
Rawlings, J. S., Rosler, K. M., & Harrison, D. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.00963 · Cited by 1,858
Self-citationStem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
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Interaction between RasV12 and scribbled clones induces tumour growth and invasion
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Border-cell migration: the race is on
Montell, D. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1006 · Cited by 329
Paradkar, P. N., Trinidad, L., Voysey, R., Duchemin, J.-B., & Walker, P. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205231109 · Cited by 329
Metadata
- Authors
- Harrison, D. A., McCoon, P. E., Binari, R., Gilman, M., & Perrimon, N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-10-15
- Volume
- 12
- Issue
- 20
- Pages
- 3252-3263
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2151418659
- Cited by
- 391
- References
- 49
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Harrison, D. A., McCoon, P. E., Binari, R., Gilman, M., & Perrimon, N. (1998). Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes & Development. https://doi.org/10.1101/gad.12.20.3252
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