The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs
Open accessAbstract
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB). This factor, termed DRB sensitivity-inducing factor (DSIF), is also required for transcription inhibition by H8. DSIF has been purified and is composed of 160-kD (p160) and 14-kD (p14) subunits. Isolation of a cDNA encoding DSIF p160 shows it to be a homolog of the Saccharomyces cerevisiae transcription factor Spt5. Recombinant Supt4h protein, the human homolog of yeast Spt4, is functionally equivalent to DSIF p14, indicating that DSIF is composed of the human homologs of Spt4 and Spt5. In addition to its negative role in elongation, DSIF is able to stimulate the rate of elongation by RNA Pol II in a reaction containing limiting concentrations of ribonucleoside triphosphates. A role for DSIF in transcription elongation is further supported by the fact that p160 has a region homologous to the bacterial elongation factor NusG. The combination of biochemical studies on DSIF and genetic analysis of Spt4 and Spt5 in yeast, also in this issue, indicates that DSIF associates with RNA Pol II and regulates its processivity in vitro and in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Phosphorylation of Ser5 of the Pol II CTD by transcription factor IIH (TFIIH) is required for transcription initiation, whereas phosphorylation of Ser2 of the Pol II CTD, of DSIF (DRB sensitivity inducing factor) and of NELF (negative elongation factor) by pTEFb (positive transcription elongation factor) is needed for transcription elongation141–143.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [141]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Multiple sequence alignment with hierarchical clustering.
Corpet, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.22.10881 · Cited by 5,575
Frohman, M. A., Dush, M. K., & Martin, G. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8998 · Cited by 4,554
Hidaka, H., Inagaki, M., Kawamoto, S., & Sasaki, Y. (1984) · Biochemistry · doi:10.1021/bi00316a032 · Cited by 2,688
The role of general initiation factors in transcription by RNA polymerase II
ROEDER, R. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10050-5 · Cited by 1,009
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitroPreprint
Zhu, Y., Peery, T., Peng, J., Ramanathan, Y., Marshall, N. F., Marshall, T. K., Amendt, B. A., Mathews, M. B., & Price, D. H. (1997) · Genes & Development · doi:10.1101/gad.11.20.2622 · Cited by 700
Rougvie, A. E., & Lis, J. T. (1988) · Cell · doi:10.1016/s0092-8674(88)91087-2 · Cited by 680
Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase
Marshall, N. F., Peng, J., Xie, Z., & Price, D. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.27176 · Cited by 662
Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
Winston, F., & Carlson, M. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90300-s · Cited by 574
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 751
TFS and Spt4/5 accelerate transcription through archaeal histone‐based chromatin
Sanders, T. J., Lammers, M. L., Marshall, C. J., Walker, J. E., Lynch, E. R., & Santangelo, T. J. (2018) · Molecular Microbiology · doi:10.1111/mmi.14191 · Cited by 30
PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation
Páhi, Z. G., Borsos, B. N., Pantazi, V., Újfaludi, Z., & Pankotai, T. (2020) · Cancers · doi:10.3390/cancers12010183 · Cited by 31
Allosteric transcription stimulation by RNA polymerase II super elongation complex
Chen, Y., Vos, S. M., Dienemann, C., Ninov, M., Urlaub, H., & Cramer, P. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.019 · Cited by 32
Li, S., Ding, B., Chen, R., Ruggiero, C., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01656-06 · Cited by 31
HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology
Thompson, L., Genovese, J., Hong, Z., Singh, M. V., & Singh, V. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094697 · Cited by 35
Fujita, T., Ryser, S., Tórtola, S., Piuz, I., & Schlegel, W. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1138 · Cited by 30
Clement, J. Q., & Wilkinson, M. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3745 · Cited by 30
Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation
Barborič, M., Zhang, F., Beseničar, M. P., Plemenitaš, A., & Peterlin, B. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11135-11141.2005 · Cited by 30
The Where and the How of PRMT5
Koh, C. M., Bezzi, M., & Guccione, E. (2015) · Current Molecular Biology Reports · doi:10.1007/s40610-015-0003-5 · Cited by 29
Wenzel, S., Martins, B. M., ROSCH, P. J., & Wöhrl, B. M. (2009) · Biochemical Journal · doi:10.1042/bj20091422 · Cited by 29
Abe, K., Schauer, T., & Torres‐Padilla, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111865 · Cited by 29
A balance of positive and negative regulators determines the pace of the segmentation clock
Wiedermann, G. E., Bone, R. A., Silva, J. C., Bjorklund, M., Murray, P. J., & Dale, J. K. (2015) · eLife · doi:10.7554/elife.05842 · Cited by 26
A meiosis-specific Spt5 homolog involved in non-coding transcription
Gruchota, J., Wilkes, C. D., Arnaiz, O., Sperling, L., & Nowak, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1318 · Cited by 29
cis Elements that Mediate RNA Polymerase II Pausing Regulate Human Gene Expression
Watts, J. A., Burdick, J. T., Daigneault, J., Zhu, Z., Grunseich, C., Bruzel, A., & Cheung, V. G. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.08.003 · Cited by 32
Yamaguchi, Y., Deléhouzée, S., & Handa, H. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01641-6 · Cited by 29
Self-citationThe Sensitivity of RNA Polymerase II in Elongation Complexes to C-terminal Domain Phosphatase
Lehman, A. L., & Dahmus, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.14923 · Cited by 29
High‐wire act: the poised genome and cellular memory
Puri, D., Gala, H., Mishra, R. K., & Dhawan, J. (2014) · FEBS Journal · doi:10.1111/febs.13165 · Cited by 26
Basis of gene-specific transcription regulation by the Integrator complex
Sabath, K., Nabih, A., Arnold, C., Moussa, R., Domjan, D., Zaugg, J. B., & Jonas, S. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.05.027 · Cited by 30
Sun, J., Pan, H., Lei, C., Yuan, B., Nair, S. J., April, C., Parameswaran, B., Klotzle, B., Fan, J., Ruan, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.269167 · Cited by 28
Regulation of RNA Polymerase II Termination by Phosphorylation of Gdown1
Guo, J., Turek, M. E., & Price, D. H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537662 · Cited by 26
Molecular Characterization of Genomic Activities at the Onset of Zygotic Transcription in Mammals1
Pacheco-Trigon, S., Hennequet‐Antier, C., Oudin, J.-F., Piumi, F., Renard, J. P. J. P., & Duranthon, V. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.6.1907 · Cited by 28
Genomic organization and characterization of promoter function of the human CDK9 gene
Liu, H., & Rice, A. P. (2000) · Gene · doi:10.1016/s0378-1119(00)00215-8 · Cited by 28
A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation
Liu, Z., Zhou, Z., Chen, G., & Bao, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.133 · Cited by 28
SUPT4H1 Depletion Leads to a Global Reduction in RNA
Naguib, A., Sandmann, T., Yi, F., Watts, R. J., Lewcock, J. W., & Dowdle, W. E. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.004 · Cited by 27
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang, J. K., Alt, F. W., & Yeap, L.-S. (2015) · ASM Press eBooks · doi:10.1128/9781555819217.ch15 · Cited by 29
Regulation of the epigenome through RNA modifications
Patrasso, E. A., Raikundalia, S., & Arango, D. (2023) · Chromosoma · doi:10.1007/s00412-023-00794-7 · Cited by 27
RNA polymerase II pausing and transcriptional regulation of the HSP70 expression
Bunch, H. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.09.003 · Cited by 27
Chan, C. L., & Gross, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104764200 · Cited by 27
Zhu, W., Wada, T., Okabe, S., Taneda, T., Yamaguchi, Y., & Handa, H. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm430 · Cited by 27
Self-citationZhang, R., Wu, J., Ferrandon, S., Glowacki, K. J., & Houghton, J. A. (2016) · Oncotarget · doi:10.18632/oncotarget.13376 · Cited by 27
Ren, D., Lei, L., & Burton, Z. F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7377 · Cited by 27
A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes
Chwalenia, K., Qin, F., Singh, S., & Li, H. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1288 · Cited by 26
Concerted Transcriptional Regulation by BRCA1 and COBRA1 in Breast Cancer Cells
Aiyar, S. E., Cho, H., Lee, J., & Li, R. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.486 · Cited by 26
Global profiling of influence of intra-ischemic brain temperature on gene expression in rat brain
Kobayashi, M. S., Asai, S., Ishikawa, K., Nishida, Y., Nagata, T., & Takahashi, Y. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.03.001 · Cited by 27
Marshall, N. F., & Dahmus, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005898200 · Cited by 26
Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rate
García, A., Collin, A., & Calvo, O. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-04-0331 · Cited by 25
Howard, S. C., Hester, A., & Herman, P. K. (2003) · Genetics · doi:10.1093/genetics/165.3.1059 · Cited by 25
Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis
Komori, T., Inukai, N., Yamada, T., Yamaguchi, Y., & Handa, H. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01273.x · Cited by 27
Self-citationRegulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells
Aiyar, S. E., Blair, A. L., Hopkinson, D. A., Bekiranov, S., & Li, R. (2006) · Oncogene · doi:10.1038/sj.onc.1210047 · Cited by 25
Yoshida, M., Kabe, Y., Wada, T., Asai, A., & Handa, H. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.043307 · Cited by 25
Self-citationTranscription elongation: The ‘Foggy’ is lifting…
Zorio, D. A. R., & Bentley, D. L. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00063-x · Cited by 25
Leporé, N., & Lafontaine, D. L. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024962 · Cited by 24
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development
Pipkin, M. E. (2021) · Immunological Reviews · doi:10.1111/imr.12954 · Cited by 24
Amir-Zilberstein, L., & Dikstein, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706767200 · Cited by 24
Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination
Robert, I., Gaudot, L., Rogier, M., Heyer, V., Noll, A., Dantzer, F., & Reina‐San‐Martin, B. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005240 · Cited by 27
Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL
Schuelein, R., Spencer, H., Dagley, L. F., Li, P. F., Luo, L., Stow, J. L., Abraham, G., Naderer, T., Gómez-Valero, L., Buchrieser, C., et al. (2018) · Cellular Microbiology · doi:10.1111/cmi.12852 · Cited by 24
The hunt for RNA polymerase II elongation factors: a historical perspective
Conaway, R., & Conaway, J. W. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0283-1 · Cited by 27
Interplay of mRNA capping and transcription machineries
Kachaev, Z. M., Lebedeva, L. A., Kozlov, E., & Shidlovskii, Y. V. (2020) · Bioscience Reports · doi:10.1042/bsr20192825 · Cited by 24
Vanti, M., Gallastegui, E., Respaldiza, I., Rodríguez‐Gil, A., Gómez-Herreros, F., Jimeno-González, S., Jordan, A., & Chávez, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000339 · Cited by 23
Elongin from Saccharomyces cerevisiae
Koth, C. M., Botuyan, M. V., Moreland, R. J., Jansma, D. B., Conaway, J. W., Conaway, R. C., Chazin, W., Friesen, J. D., Arrowsmith, C. H., & Edwards, A. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11174 · Cited by 24
Cacioppo, R., Gillis, A., Shlamovitz, I., Zeller, A., Castiblanco, D., Crisp, A., Haworth, B., Arabiotorre, A., Abyaneh, P., Bao, Y., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.024 · Cited by 26
Imashimizu, M., Shimamoto, N., Oshima, T., & Kashlev, M. (2014) · Transcription · doi:10.4161/trns.28285 · Cited by 25
Analysis of Polymerase II Elongation Complexes by Native Gel Electrophoresis
Zhang, Z., Wu, C.-H., & Gilmour, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402956200 · Cited by 23
Activation of a Poised RNAPII-Dependent Promoter Requires Both SAGA and Mediator
Lee, S. K., Fletcher, A. G. L., Zhang, L., Chen, X., Fischbeck, J. A., & Stargell, L. A. (2010) · Genetics · doi:10.1534/genetics.109.113464 · Cited by 24
RNA polymerase II pausing as a context-dependent reader of the genome
Scheidegger, A., & Nechaev, S. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2015-0045 · Cited by 23
Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation
Cassina, M., Cagnoli, G. A., Zuccarello, D., Gianantonio, E. D., & Clementi, M. (2016) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2016.09.011 · Cited by 26
Bahat, A., Lahav, O., Plotnikov, A. N., Leshkowitz, D., & Dikstein, R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.024 · Cited by 23
A combinatorial view of old and new RNA polymerase II modifications
Lyons, D. E., McMahon, S., & Ott, M. (2020) · Transcription · doi:10.1080/21541264.2020.1762468 · Cited by 22
Dreikhausen, U., Hiebenthal-Millow, K., Bartels, M., Resch, K., & Nourbakhsh, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7473-7483.2005 · Cited by 23
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription
Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Cao, Q.-F., Egloff, S., Handa, H., & Murphy, S. (2015) · Transcription · doi:10.1080/21541264.2015.1095269 · Cited by 23
Self-citationNus Factors of Escherichia coli
Sen, R., Chalissery, J., & Muteeb, G. (2008) · EcoSal Plus · doi:10.1128/ecosalplus.4.5.3.1 · Cited by 24
Kim, D., Inukai, N., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Wada, T., & Handa, H. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00638.x · Cited by 23
Self-citationLysakovskaia, K., Devadas, A., Schwalb, B., Lidschreiber, M., & Cramer, P. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01486-9 · Cited by 22
Mota, T. M., McCann, C. D., Danesh, A., Huang, S.-H., Magat, D., Ren, Y., Leyre, L., Bui, T. D., Rohwetter, T. M., Kovacs, C. M., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01845-19 · Cited by 23
Guo, C., Zhang, Y., Shuai, S., Sigbessia, A., Hao, S., Xie, P., Jiang, X., Luo, Z., & Lin, C. (2023) · EMBO Reports · doi:10.15252/embr.202255699 · Cited by 20
Kuś, K., Carrique, L., Kecman, T., Fournier, M. L., Hassanein, S. S., Aydin, E., Kilchert, C., Grimes, J. M., & Vasiljeva, L. (2025) · Nature Communications · doi:10.1038/s41467-024-55063-7 · Cited by 20
Klatt, A., Zhang, Z., Kalantari, P., Hankey, P. A., Gilmour, D. S., & Henderson, A. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1670 · Cited by 22
Pujari, V., Radebaugh, C. A., Chodaparambil, J. V., Muthurajan, U. M., Almeida, A. R., Fischbeck, J. A., Luger, K., & Stargell, L. A. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.09.040 · Cited by 23
Fujita, T., Piuz, I., & Schlegel, W. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.10.032 · Cited by 25
Mammalian transcription factors in yeast: strangers in a familiar land
Kennedy, B. K. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm704 · Cited by 22
The Regulation of Elongation by Eukaryotic RNA Polymerase II: A Recent View
Kim, D.-K., Yamaguchi, Y., Wada, T., & Handa, H. (2001) · Molecules and Cells · doi:10.1016/s1016-8478(23)17035-x · Cited by 22
Self-citationStructural perspectives on transcription in chromatin
Sekine, S., Ehara, H., Kujirai, T., & Kurumizaka, H. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.011 · Cited by 21
Regulation of transcription elongation in response to osmostress
Silva, A., Cavero, S. C., Begley, V., Solé, C., Böttcher, R., Chávez, S., Posas, F., & de Nadal, E. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007090 · Cited by 21
Michel, N., Goffinet, C., Ganter, K., Allespach, I., KewalRamani, V. N., Saifuddin, M., Littman, D. R., Greene, W. C., Goldsmith, M. A., & Keppler, O. T. (2009) · Retrovirology · doi:10.1186/1742-4690-6-2 · Cited by 21
Partners in crime: Proteins implicated in RNA repeat expansion diseases
Baud, A., Derbis, M., Tutak, K., & Sobczak, K. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1709 · Cited by 20
RNA Polymerase II transcription independent of TBP in murine embryonic stem cells
Kwan, J. Z. J., Nguyen, T. F., Uzozie, A. C., Budzyński, M. A., Cui, J. H., Lee, J. M., Petegem, F. V., Lange, P. F., & Teves, S. S. (2023) · eLife · doi:10.7554/elife.83810 · Cited by 19
Wada, T., Hara, M., Taneda, T., Qingfu, C., Takata, R., Moro, K., Takeda, K., Kishimoto, T., & Handa, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks765 · Cited by 20
Self-citationFujita, T., Piuz, I., & Schlegel, W. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.050 · Cited by 20
Hu, X., & Chen, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00179 · Cited by 19
Latency Reversing Agents: Kick and Kill of HTLV-1?
Schnell, A. P., Kohrt, S., & Thoma‐Kress, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115545 · Cited by 22
Transcription activation by targeted recruitment of the RNA polymerase II CTD phosphatase FCP1
Licciardo, P. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.3539 · Cited by 19
The HIV-1 Transcriptional Program: From Initiation to Elongation Control
D’Orso, I. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168690 · Cited by 21
Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome
Naganuma, M., Kujirai, T., Ehara, H., Uejima, T., Ito, T., Goto, M., Aoki, M., Henmi, M., Miyamoto-Kohno, S., Shirouzu, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu0577 · Cited by 18
Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb
Huang, F., Nguyen, T. T. T., Echeverria, I., Ramachandran, R., Cary, D. C., Paculova, H., Šali, A., Weiss, A., Peterlin, B. M., & Fujinaga, K. (2021) · eLife · doi:10.7554/elife.68473 · Cited by 17
Zhang, X., van Heusden, G. P. H., & Hooykaas, P. J. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706166114 · Cited by 20
Gómez-Herreros, F., Margaritis, T., Rodríguez‐Galán, O., Pelechano, V., Begley, V., Millán-Zambrano, G., Morillo‐Huesca, M., Muñoz-Centeno, M. C., Pérez-Ortín, J. E., de la Cruz, J., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx529 · Cited by 18
Ubukata, T., Shimizu, T., Adachi, N., Sekimizu, K., & Nakanishi, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211384200 · Cited by 18
Cyclin T2A Gene Maps on Human Chromosome 2q21
Luca, A. D., Tosolini, A., Russo, P., Severino, A., Baldi, A., Luca, L. D., Cavallotti, I., Baldi, F., Giordano, A., Testa, J. R., et al. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104900603 · Cited by 18
Bertucci, P. Y., Nacht, A. S., Alló, M., Rocha-Viegas, L., Ballaré, C., Soronellas, D., Castellano, G., Zaurín, R., Kornblihtt, A. R., Beato, M., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt327 · Cited by 19
Zuber, P. K., Hahn, L., Reinl, A., Schweimer, K., Knauer, S. H., Gottesman, M. E., ROSCH, P. J., & Wöhrl, B. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-30042-3 · Cited by 17
The transient Spt4-Spt5 complex as an upstream regulator of non-coding RNAs during development
Owsian, D., Gruchota, J., Arnaiz, O., & Nowak, J. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac106 · Cited by 17
Dioxin-inducible Transactivation in a Chromosomal Setting
Jones, L. C., & Whitlock, J. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102910200 · Cited by 17
SPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition
Aoi, Y., Iravani, L., Mroczek, I. C., Gold, S. R., Howard, B. C., & Shilatifard, A. (2025) · Science Advances · doi:10.1126/sciadv.adt5885 · Cited by 16
Dollinger, R., Deng, E. B., Schultz, J., Wu, S. K., Deorio, H. R., & Gilmour, D. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105106 · Cited by 16
Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma
Walker, R. L., Hornicek, F. J., & Duan, Z. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116342 · Cited by 16
The CDK9-SPT5 Axis in Control of Transcription Elongation by RNAPII
Sun, R., & Fisher, R. P. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168746 · Cited by 16
The chromatin remodeler Ino80 mediates RNAPII pausing site determination
Cheon, Y., Han, S., Kim, T., Hwang, D., & Lee, D. (2021) · Genome biology · doi:10.1186/s13059-021-02500-1 · Cited by 14
Cooper, K. L., Armstrong, J., & Moens, C. B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20584 · Cited by 16
Chromatin alteration, transcription and replication: What's the opening line to the story?
Barton, M. C., & Crowe, A. J. (2001) · Oncogene · doi:10.1038/sj.onc.1204334 · Cited by 16
Mechanism of H‐8 inhibition of Cyclin‐dependent kinase 9: study using inhibitor‐immobilized matrices
Shima, D., Yugami, M., Tatsuno, M., Wada, T., Yamaguchi, Y., & Handa, H. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00627.x · Cited by 16
Self-citation
Metadata
- Authors
- Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G. A., Winston, F., Buratowski, S., & Handa, H.
- Affiliations
- National Institute of Genetics (JP)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-02-01
- Volume
- 12
- Issue
- 3
- Pages
- 343-356
- ISSN
- 0890-9369 (ISSN-L)
- PMC
- PMC316480
- OpenAlex
- W2148917483
- Cited by
- 750
- References
- 77
- Citations by year
- 2026: 23 · 2025: 18 · 2024: 33 · 2023: 20 · 2022: 24 · 2021: 38 · 2020: 32 · 2019: 24 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 31 · 2012: 28
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM032967, R37GM032967, GM 32967)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- DSIF, transcription elongation, RNA polymerase II, processivity, Spt4, Spt5, transcriptional pausing, HeLa cells, Saccharomyces cerevisiae, cDNA cloning
- MeSH terms
- Amino Acid Sequence, Chromosomal Proteins, Non-Histone, Dichlororibofuranosylbenzimidazole, Fungal Proteins, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, RNA Polymerase II, Saccharomyces cerevisiae, Sensitivity and Specificity, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Sequence Homology, Amino Acid, Nucleic Acid Synthesis Inhibitors, Saccharomyces cerevisiae Proteins, Transcriptional Elongation Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review