The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
Open accessAbstract
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.
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Citations
Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature · doi:10.1038/373432a0 · Cited by 938
Self-citationMaltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Robb, L., Lyons, I., Li, R., Hartley, L., Köntgen, F., Harvey, R. P., Metcalf, D., & Begley, C. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7075 · Cited by 577
The transcriptional control of hematopoiesis [see comments]
Shivdasani, R., & Orkin, S. (1996) · Blood · doi:10.1182/blood.v87.10.4025.bloodjournal87104025 · Cited by 560
Self-citationWeiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.10.1184 · Cited by 541
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Cited by
Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
Dumont, D. J., Jussila, L., Taipale, J., Lymboussaki, A., Mustonen, T., Pajusola, K., Breitman, M., & Alitalo, K. (1998) · Science · doi:10.1126/science.282.5390.946 · Cited by 874
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
Transcriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
Hedgehog is required for murine yolk sac angiogenesis
Byrd, N., Becker, S., Maye, P., Narasimhaiah, R., St-Jacques, B., Zhang, X., McMahon, J., McMahon, A., & Grabel, L. (2002) · Development · doi:10.1242/dev.129.2.361 · Cited by 257
Göttgens, B., Nastos, A., Kinston, S., Piltz, S., Delabesse, E. C. M., Stanley, M., Sanchez, M., Ciau‐Uitz, A., Patient, R., & Green, A. R. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf286 · Cited by 212
Metadata
- Authors
- Visvader, J. E., Fujiwara, Y., & Orkin, S. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-02-15
- Volume
- 12
- Issue
- 4
- Pages
- 473-479
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2101466764
- Cited by
- 328
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. https://app.cochat.ai/papers/10.1101/gad.12.4.473
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- Visvader, J. E., Fujiwara, Y., & Orkin, S. H. (1998). Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes & Development. https://doi.org/10.1101/gad.12.4.473
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
