The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
Abstract
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. Here it is shown that targeted inactivation of the gene encoding VEGFR-3 resulted in defective blood vessel development in early mouse embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
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Cites
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The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,330
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
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Self-citationWang, H. U., Chen, Z.-F., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,669
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Self-citationHyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
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Cited by
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Self-citationA dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198
Self-citationMolecular mechanisms of blood vessel growth
Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030
Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C.-O., Buerk, D. G., Huang, P. L., & Jain, R. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041359198 · Cited by 1,020
Metadata
- Authors
- Dumont, D. J., Jussila, L., Taipale, J., Lymboussaki, A., Mustonen, T., Pajusola, K., Breitman, M., & Alitalo, K.
- Venue
- Science
- Published
- 1998-10-30
- Volume
- 282
- Issue
- 5390
- Pages
- 946-949
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013730676
- Cited by
- 874
- References
- 29
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3. https://app.cochat.ai/papers/10.1126/science.282.5390.946
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- Dumont, D. J., Jussila, L., Taipale, J., Lymboussaki, A., Mustonen, T., Pajusola, K., Breitman, M., & Alitalo, K. (1998). Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3. Science. https://doi.org/10.1126/science.282.5390.946
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
