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Cited by 345

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish

Open access
Liao, E. C., Paw, B. H., Oates, A. C., Pratt, S. J., Postlethwait, J. H., Zon, L. I.·1998·Genes & Development

Abstract

SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the clo mutation is not linked to the SCL locus. Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation.

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Metadata

Authors
Liao, E. C., Paw, B. H., Oates, A. C., Pratt, S. J., Postlethwait, J. H., & Zon, L. I.
Venue
Genes & Development
Published
1998-03-01
Volume
12
Issue
5
Pages
621-626
ISSN
0890-9369 (ISSN-L)
OpenAlex
W2013971533
Cited by
345
References
2
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. https://app.cochat.ai/papers/10.1101/gad.12.5.621
The paper
Liao, E. C., Paw, B. H., Oates, A. C., Pratt, S. J., Postlethwait, J. H., & Zon, L. I. (1998). SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes & Development. https://doi.org/10.1101/gad.12.5.621

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