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RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange
Open accessAbstract
With the discovery that the Saccharomyces cerevisiae Rad51 protein is both structurally and functionally similar to the Escherichia coli RecA protein, the RecA paradigm for homologous recombination was extended to the Eucarya. The ubiquitous presence of RecA and Rad51 protein homologs raises the question of whether this archetypal protein exists within the third domain of life, the Archaea. Here we present the isolation of a Rad51/RecA protein homolog from the archaeon Sulfolobus solfataricus, and show that this protein, RadA, possesses the characteristics of a DNA strand exchange protein: The RadA protein is a DNA-dependent ATPase, forms a nucleoprotein filament on DNA, and catalyzes DNA pairing and strand exchange.
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Cites
Woese, C. R. (1987) · Microbiological Reviews · doi:10.1128/mr.51.2.221-271.1987 · Cited by 5,042
Cited by
The Bacterial RecA Protein and the Recombinational DNA Repair of Stalled Replication Forks
Lusetti, S. L., & Cox, M. M. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.133940 · Cited by 428
Regulation of Bacterial RecA Protein Function
Cox, M. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701260258 · Cited by 417
Lin, Z., Kong, H., Nei, M., & Ma, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604232103 · Cited by 294
Archaeal genetics — the third way
Allers, T., & Mevarech, M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1504 · Cited by 265
Repair of DNA Double-Strand Breaks following UV Damage in Three Sulfolobussolfataricus Strains
Rolfsmeier, M. L., Laughery, M. F., & Haseltine, C. A. (2010) · Journal of Bacteriology · doi:10.1128/jb.00667-10 · Cited by 42
Metadata
- Authors
- Seitz, E. M., Brockman, J. P., Sandler, S. J., Clark, A. J., & Kowalczykowski, S. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-05-01
- Volume
- 12
- Issue
- 9
- Pages
- 1248-1253
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2098110766
- Cited by
- 196
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange. https://app.cochat.ai/papers/10.1101/gad.12.9.1248
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- Seitz, E. M., Brockman, J. P., Sandler, S. J., Clark, A. J., & Kowalczykowski, S. C. (1998). RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange. Genes & Development. https://doi.org/10.1101/gad.12.9.1248
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
