The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step
Open accessAbstract
RNA silencing suppressors from different plant viruses are structurally diverse. In addition to inhibiting the antiviral silencing response to condition susceptibility, many suppressors are pathogenicity factors that cause disease or developmental abnormalities. Here, unrelated suppressors from multiple viruses were shown to inhibit microRNA (miRNA) activities and trigger an overlapping series of severe developmental defects in transgenic Arabidopsis thaliana . This suggests that interference with miRNA-directed processes may be a general feature contributing to pathogenicity of many viruses. A normally labile intermediate in the miRNA biogenesis/RNA-induced silencing complex (RISC) assembly pathway, miRNA*, accumulated specifically in the presence of suppressors (P1/HC-Pro, p21, or p19) that inhibited miRNA-guided cleavage of target mRNAs. Both p21 and p19, but not P1/HC-Pro, interacted with miRNA/miRNA* complexes and hairpin RNA-derived short interfering RNAs (siRNAs) in vivo. In addition, p21 bound to synthetic miRNA/miRNA* and siRNA duplexes in vitro. We propose that several different suppressors act by distinct mechanisms to inhibit the incorporation of small RNAs into active RISCs.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA
Llave, C., Xie, Z., Kasschau, K. D., & Carrington, J. C. (2002) · Science · doi:10.1126/science.1076311 · Cited by 1,627
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Cited by
microRNA biogenesis and function in plants
Chen, X. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.071 · Cited by 567
Technical variables in high-throughput miRNA expression profiling: much work remains to be done
NELSON, P., WANG, W., WILFRED, B., & TANG, G. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.03.012 · Cited by 92
Metadata
- Authors
- Chapman, E. J., Prokhnevsky, A. I., Gopinath, K., Dolja, V. V., & Carrington, J. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-05-06
- Volume
- 18
- Issue
- 10
- Pages
- 1179-1186
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2109590074
- Cited by
- 583
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Chapman, E. J., Prokhnevsky, A. I., Gopinath, K., Dolja, V. V., & Carrington, J. C. (2004). Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step. Genes & Development. https://doi.org/10.1101/gad.1201204
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