Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA
Abstract
Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also known as miR171), a 21-ribonucleotide species that accumulates predominantly in inflorescence tissues, is produced from an intergenic region in chromosome III and functionally interacts with mRNA targets encoding several members of the Scarecrow-like ( SCL ) family of putative transcription factors. miRNA 39 is complementary to an internal region of three SCL mRNAs. The interaction results in specific cleavage of target mRNA within the region of complementarity, indicating that this class of miRNA functions like small interfering RNA associated with RNA silencing to guide sequence-specific cleavage in a developmentally controlled manner.
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In plants, miRNAs have greater complementarity to their mRNA targets and are likely to trigger degradation of their targets similarly to small interfering RNAs.
“In plants, miRNAs have greater complementarity to their mRNA targets, and are likely to trigger the degradation of their targets similarly to the action of small interfering RNAs (siRNAs; Llave et al. 2002;Rhoades et al. 2002).”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Llave et al. 2002
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Processing of primary microRNAs by the Microprocessor complex
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Abiotic Stress Responses in Plants: Unraveling the Complexity of Genes and Networks to Survive
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- Authors
- Llave, C., Xie, Z., Kasschau, K. D., & Carrington, J. C.
- Affiliations
- Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.
- Venue
- Science
- Published
- 2002-09-20
- Volume
- 297
- Issue
- 5589
- Pages
- 2053-2056
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 1,393
- References
- 3
- Language
- en
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