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Cited by 293

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Form follows function: the genomic organization of cellular differentiation

Open access
Kosak, Steven T., Groudine, Mark·2004·Genes & Development

Abstract

The extent to which the nucleus is functionally organized has broad biological implications. Evidence supports the idea that basic nuclear functions, such as transcription, are structurally integrated within the nucleus. Moreover, recent studies indicate that the linear arrangement of genes within eukaryotic genomes is nonrandom. We suggest that determining the relationship between nuclear organization and the linear arrangement of genes will lead to a greater understanding of how transcriptomes, dedicated to a particular cellular function or fate, are coordinately regulated. Current network theories may provide a useful framework for modeling the inherent complexity the functional organization of the nucleus.

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Metadata

Authors
Kosak, S. T., & Groudine, M.
Venue
Genes & Development
Published
2004-06-15
Volume
18
Issue
12
Pages
1371-1384
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2099449240
Cited by
293
References
6
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Form follows function: the genomic organization of cellular differentiation. https://app.cochat.ai/papers/10.1101/gad.1209304
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Kosak, S. T., & Groudine, M. (2004). Form follows function: the genomic organization of cellular differentiation. Genes & Development. https://doi.org/10.1101/gad.1209304

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