Cited by 1,321RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

RNA regulons: coordination of post-transcriptional events

Keene, Jack D.·2007·Nature Reviews Genetics

Abstract

Recent findings demonstrate that multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation. These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism. Here I describe several recently discovered examples of RNA operons in budding yeast, fruitfly and mammalian cells, and their potential importance in processes such as immune response, oxidative metabolism, stress response, circadian rhythms and disease. I close by considering the evolutionary wiring and rewiring of these combinatorial post-transcriptional gene-expression networks.

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Crossref · 10.1038/nrg2111

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  • RNA-binding proteins control many steps of co- and post-transcriptional gene expression, such as splicing, polyadenylation, capping, modification, export, localization, translation, and turnover.

    “RNA-binding proteins (RBPs) regulate numerous aspects of co- and post-transcriptional gene expression, including RNA splicing, polyadenylation, capping, modification, export, localization, translation and turnover1,2.”

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Authors
Keene, J. D.
Affiliations
Duke University (US)
Corresponding author
Keene, Jack D.
Venue
Nature Reviews Genetics
Published
2007-07
Volume
8
Issue
7
Pages
533-543
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2073424121
Cited by
1,321
References
134
Citations by year
2026: 27 · 2025: 29 · 2024: 48 · 2023: 49 · 2022: 58 · 2021: 59 · 2020: 74 · 2019: 62 · 2018: 72 · 2017: 74 · 2016: 72 · 2015: 74 · 2014: 98 · 2013: 80 · 2012: 95
FWCI
6.56
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
RNA-binding proteins, post-transcriptional regulation, ribonucleoprotein complexes, mRNA splicing, mRNA export, mRNA stability, mRNA localization, translation (biology), cell differentiation, immune response, oxidative metabolism, stress response, circadian rhythm, gene expression networks, gene regulatory evolution
MeSH terms
Animals, Drosophila, Saccharomycetales, Gene Expression Regulation, Mammals, Models, Genetic, Operon, RNA, RNA Processing, Post-Transcriptional, RNA Splicing, Transcription, Genetic, Protein Biosynthesis, RNA-Binding Proteins, Regulon, Gene Regulatory Networks

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