The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
Open accessAbstract
Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to telomere length control through recruitment of POT1.
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“TRF1-interacting nuclear factor 2 also interacts with the subcomplex of shelterin that binds the single-stranded overhang-TPP1 and POT1, two oligonucleotide/ oligosaccharide binding (OB)-fold containing proteins (13)(14)(15).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [14]
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Cites
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Smogorzewska, A., & de Lange, T. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.160049 · Cited by 813
Senescence Induced by Altered Telomere State, Not Telomere Loss
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A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells
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Control of Human Telomere Length by TRF1 and TRF2
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POT1 as a terminal transducer of TRF1 telomere length control
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Research works printed but not linked: 2
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- Liu D ., Safari, A., O'Conner, M.S., Chan, D.W., Laegeler, A., Qin, L., and Songyang, Z. 2004. PTOP is a novel POT1 interacting protein that regulates POT1 telomeric localization. Nat. Cell Biol. (in press).
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Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880
G-quadruplex structures: in vivo evidence and function
Lipps, H. J., & Rhodes, D. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.002 · Cited by 856
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823
Metadata
- Authors
- Ye, J. Z.-S., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., & de Lange, T.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-07-01
- Volume
- 18
- Issue
- 14
- Pages
- 1649-1654
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC478187
- OpenAlex
- W2155983703
- Cited by
- 459
- References
- 21
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 18 · 2022: 6 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 30 · 2015: 21 · 2014: 34 · 2013: 17 · 2012: 24
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RR00862)
- National Cancer Institute (K08 CA93604, K08CA093604, T32 CA09673-26A1, T32CA009673)
- National Center for Research Resources (RR00862, P41RR000862)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- PIP1, POT1, TIN2, TRF1, telomere length regulation, telomeric proteins, telomerase inhibition, telomere elongation, protein-protein interaction, telomeric DNA
- MeSH terms
- Shelterin Complex, Carrier Proteins, Cloning, Molecular, Fluorescent Antibody Technique, HeLa Cells, Humans, Mass Spectrometry, Telomere, Two-Hybrid System Techniques, Telomere-Binding Proteins, RNA Interference, Telomeric Repeat Binding Protein 1, Intracellular Signaling Peptides and Proteins
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