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LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
Open accessAbstract
Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate somitogenesis. Here, we examine the molecular basis for this presumed hierarchy and show that a targeted mutation of Lef1 , which abrogates LEF1 function and impairs the activity of coexpressed TCF factors, affects the patterning of somites and the expression of components of the Notch pathway. LEF1 was found to bind multiple sites in the Dll1 promoter in vitro and in vivo. Moreover, mutations of LEF1-binding sites in the Dll1 promoter impair expression of a Dll1–LacZ transgene in the presomitic mesoderm. Finally, the induced expression of LEF1–β-catenin activates the expression of endogenous Dll1 in fibroblastic cells. Thus, Wnt signaling can affect the Notch pathway by a LEF1-mediated regulation of Dll1 .
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Citations
Cited by
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
Notch signals control the fate of immature progenitor cells in the intestine
Fre, S., Huyghe, M., Mourikis, P., Robine, S., Louvard, D., & Artavanis-Tsakonas, S. (2005) · Nature · doi:10.1038/nature03589 · Cited by 935
Signaling and transcriptional regulation in osteoblast commitment and differentiation
Huang, W. (2007) · Frontiers in Bioscience · doi:10.2741/2296 · Cited by 649
Developmental regulation of the Hox genes during axial morphogenesis in the mouse
Deschamps, J., & van Nes, J. (2005) · Development · doi:10.1242/dev.01897 · Cited by 375
WNT signalling and haematopoiesis: a WNT–WNT situation
Staal, F. J. T., & Clevers, H. C. (2005) · Nature Reviews Immunology · doi:10.1038/nri1529 · Cited by 330
Metadata
- Authors
- Galceran, J., Sustmann, C., Hsu, S.-C., Folberth, S., & Grosschedl, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-11-15
- Volume
- 18
- Issue
- 22
- Pages
- 2718-2723
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2159783062
- Cited by
- 184
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Galceran, J., Sustmann, C., Hsu, S.-C., Folberth, S., & Grosschedl, R. (2004). LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes & Development. https://doi.org/10.1101/gad.1249504
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