The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
Open accessAbstract
Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.
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Citations
Cites
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1×
“These biological effects include teratogenesis, tumor promotion, thymic atrophy, epithelial hyperplasia, hepatotoxicity, and induction of drug-metabolizing enzymes (Poland and Knutson 1982; Swanson and Bradfield 1993; Hankinson 1995; Sogawa and Fujii-Kuriyama 1997).”
BackgroundJen, Y., Weintraub, H., & Benezra, R. (1992) · Genes & Development · doi:10.1101/gad.6.8.1466 · Cited by 471
Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., & Fujii-Kuriyama, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36885-1 · Cited by 149
Self-citation
Cited by
Regulation of the immune response by the aryl hydrocarbon receptor
Gutiérrez-Vázquez, C., & Quintana, F. J. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.012 · Cited by 985
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
Tobacco smoking leads to extensive genome-wide changes in DNA methylation
Zeilinger, S., Kühnel, B., Klopp, N., Baurecht, H., Kleinschmidt, A., Gieger, C., Weidinger, S., Lattka, E., Adamski, J., Peters, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063812 · Cited by 824
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii-Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 746
Self-citationAryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
Metadata
- Authors
- Mimura, J., Ema, M., Sogawa, K., & Fujii-Kuriyama, Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 20-25
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2138913971
- Cited by
- 585
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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