The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
Open accessAbstract
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway.
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Cited by
Cyclooxygenases: Structural, cellular, and molecular biology
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Self-citationRoles of PPARs in health and disease
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Self-citation
Metadata
- Authors
- Lim, H., Gupta, R. A., Ma, W.-G., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-15
- Volume
- 13
- Issue
- 12
- Pages
- 1561-1574
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2035810647
- Cited by
- 587
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Lim, H., Gupta, R. A., Ma, W.-G., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K. (1999). Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes & Development. https://doi.org/10.1101/gad.13.12.1561
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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