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Cited by 210

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Transcription elongation factor hSPT5 stimulates mRNA capping

Open access
Wen, Y., Shatkin, A. J.·1999·Genes & Development

Abstract

RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5'-triphosphatase activity was unaffected, binding to this domain in the full-length enzyme is likely involved in the stimulation, as hSPT5 did not increase the activity of the guanylyltransferase fragment. Consistent with capping enzyme binding, TFIIH-phosphorylated CTD stimulated guanylylation, and this increase was not additive with hSPT5.

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Crossref · 10.1101/gad.13.14.1774

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Metadata

Authors
Wen, Y., & Shatkin, A. J.
Venue
Genes & Development
Published
1999-07-15
Volume
13
Issue
14
Pages
1774-1779
ISSN
0890-9369 (ISSN-L)
OpenAlex
W2046336423
Cited by
210
References
2
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Transcription elongation factor hSPT5 stimulates mRNA capping. https://app.cochat.ai/papers/10.1101/gad.13.14.1774
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Wen, Y., & Shatkin, A. J. (1999). Transcription elongation factor hSPT5 stimulates mRNA capping. Genes & Development. https://doi.org/10.1101/gad.13.14.1774

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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