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T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
Open accessAbstract
Wnt3a encodes a signal that is expressed in the primitive streak of the gastrulating mouse embryo and is required for paraxial mesoderm development. In its absence cells adopt ectopic neural fates. Embryos lacking the T-box-containing transcription factors, Brachyury or Tbx6, also lack paraxial mesoderm. Here we show that Brachyury is specifically down-regulated in Wnt3a mutants in cells fated to form paraxial mesoderm. Transgenic analysis of the T promoter identifies T (Brachyury) as a direct transcriptional target of the Wnt signaling pathway. Our results suggest that Wnt3a, signaling via Brachyury, modulates a balance between mesodermal and neural cell fates during gastrulation.
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Citations
Cited by
Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477
Hamblet, N. S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K. R., Sussman, D. J., & Wynshaw-Boris, A. (2002) · Development · doi:10.1242/dev.00164 · Cited by 441
Stem cells, signals and vertebrate body axis extension
Wilson, V., Olivera-Martinez, I., & Storey, K. G. (2009) · Development · doi:10.1242/dev.021246 · Cited by 290
Formation of the head organizer in hydra involves the canonical Wnt pathway.
Broun, M., Gee, L., Reinhardt, B., & Bode, H. R. (2005) · Development · doi:10.1242/dev.01848 · Cited by 287
Niehrs, C. (2010) · Development · doi:10.1242/dev.039651 · Cited by 283
Metadata
- Authors
- Yamaguchi, T. P., Takada, S., Yoshikawa, Y., Wu, N., & McMahon, A. P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-12-15
- Volume
- 13
- Issue
- 24
- Pages
- 3185-3190
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2099143970
- Cited by
- 527
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. https://app.cochat.ai/papers/10.1101/gad.13.24.3185
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- Yamaguchi, T. P., Takada, S., Yoshikawa, Y., Wu, N., & McMahon, A. P. (1999). T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes & Development. https://doi.org/10.1101/gad.13.24.3185
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
