The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis
Open accessAbstract
Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB. We show that bfl-1 gene expression is dependent on NF-kappaB activity and that it can substitute for NF-kappaB to suppress TNFalpha-induced apoptosis. bfl-1 promoter analysis identified an NF-kappaB site responsible for its Rel/NF-kappaB-dependent induction. The expression of bfl-1 in immune tissues supports the protective role of NF-kappaB in the immune system. The activation of Bfl-1 may be the means by which NF-kappaB functions in oncogenesis and promotes cell resistance to anti-cancer therapy.
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Cited by
Cellular survival: a play in three Akts
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Activators and target genes of Rel/NF-κB transcription factors
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Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Tumor necrosis factor signaling
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Metadata
- Authors
- Zong, W.-X., Edelstein, L. C., Chen, C., Bash, J., & Gelinas, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-02-15
- Volume
- 13
- Issue
- 4
- Pages
- 382-387
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2147760686
- Cited by
- 720
- References
- 37
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Zong, W.-X., Edelstein, L. C., Chen, C., Bash, J., & Gelinas, C. (1999). The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis. Genes & Development. https://doi.org/10.1101/gad.13.4.382
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
