The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
Open accessAbstract
The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRbeta. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230
Cited by
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Signal transduction of bone morphogenetic protein receptors
Nohe, A. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.011 · Cited by 514
Myc pathways provoking cell suicide and cancer
Nilsson, J. A., & Cleveland, J. L. (2003) · Oncogene · doi:10.1038/sj.onc.1207261 · Cited by 462
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Crane, J. L., & Cao, X. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70050 · Cited by 448
Metadata
- Authors
- Nomura, T., Khan, M. M., Kaul, S. C., Dong, H.-D., Wadhwa, R., Colmenares, C., Kohno, I., & Ishii, S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-02-15
- Volume
- 13
- Issue
- 4
- Pages
- 412-423
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2125475384
- Cited by
- 275
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Nomura, T., Khan, M. M., Kaul, S. C., Dong, H.-D., Wadhwa, R., Colmenares, C., Kohno, I., & Ishii, S. (1999). Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes & Development. https://doi.org/10.1101/gad.13.4.412
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