Signal transduction of bone morphogenetic protein receptors

TGF-β SIGNAL TRANSDUCTION

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Mechanism of activation of the TGF-β receptor

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Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

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Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

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Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

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The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

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TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4

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Smad6 inhibits signalling by the TGF-β superfamily

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Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

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Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

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Receptor-associated Mad homologues synergize as effectors of the TGF-β response

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Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

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Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somitePreprint

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Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

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A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

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Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

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A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

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MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

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Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

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Silencing of TGF-β signalling by the pseudoreceptor BAMBI

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Crystal Structure of a Smad MH1 Domain Bound to DNA

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressorPreprint

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Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

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MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

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Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

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A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

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Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

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The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

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The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways

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Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300Preprint

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SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

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Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

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The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

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TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

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Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

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The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signalingPreprint

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Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

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A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

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Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexesPreprint

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Interaction and Functional Cooperation of PEBP2/CBF with Smads

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Bone morphogenetic protein-3 is a negative regulator of bone density

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Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

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Role of Ras and Mapks in TGFβ signaling

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GDF5 Coordinates Bone and Joint Formation during Digit Development

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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway

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Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β

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The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

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The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb

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Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

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Mechanism of TGFβ receptor inhibition by FKBP12

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Measuring dimensions: the regulation of size and shape

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Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

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Physical and Functional Interaction of SMADs and p300/CBP

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Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution 1 1Edited by R. Huber

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Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development

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TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

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Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

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Negative Regulation of BMP/Smad Signaling by Tob in Osteoblasts

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Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

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Role of TGFβs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod

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Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

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Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors

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Smad proteins exist as monomers in vivo and undergo homo‐ and hetero‐oligomerization upon activation by serine/threonine kinase receptors

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Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

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The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.Preprint

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Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptorPreprint

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Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

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BMP5 and the Molecular, Skeletal, and Soft-Tissue Alterations in short ear Mice

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BMP2-induced Apoptosis Is Mediated by Activation of the TAK1-p38 Kinase Pathway That Is Negatively Regulated by Smad6

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Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

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Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-β in Normal Human Osteoblastic Cells

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Alternatively Spliced Variant of Smad2 Lacking Exon 3

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BMP7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye

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Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

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Differential Inhibition of Smad6 and Smad7 on Bone Morphogenetic Protein- and Activin-mediated Growth Arrest and Apoptosis in B Cells

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Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity

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Bone Morphogenetic Protein Receptor Type II Is a Receptor for Growth Differentiation Factor-91

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Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors

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The Role of TGF-β2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma

Wordinger, R. J., Sharma, T. P., & Clark, A. F. (2014) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2013.0220 · Cited by 133 · see citing works

Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications

Burg, E. D., Remillard, C. V., & Yuan, J. X. ‐. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707635 · Cited by 130 · see citing works

A New Subtype of Brachydactyly Type B Caused by Point Mutations in the Bone Morphogenetic Protein Antagonist NOGGIN

Lehmann, K., Seemann, P., Sılan, F., Goecke, T. O., Irgang, S., Kjaer, K. W., Kjaergaard, S., Mahoney, M. J., Morlot, S., Reißner, C., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519697 · Cited by 129 · see citing works

BMP4 regulates the hematopoietic stem cell niche

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Ras-MAPK Signaling in Osteogenic Differentiation: Friend or Foe?

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Conditional Deletion of Gremlin Causes a Transient Increase in Bone Formation and Bone Mass

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Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

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The RGM/DRAGON family of BMP co-receptors

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Intestinal stem cells

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Cell responses to bone morphogenetic proteins and peptides derived from them: Biomedical applications and limitations

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Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7

Zhao, M., Zhao, Z., Koh, J., Jin, T., & Franceschi, R. T. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20411 · Cited by 117 · see citing works

Regulation of Runx2 by MicroRNAs in osteoblast differentiation

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Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

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Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation

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Osthole-Mediated Cell Differentiation through Bone Morphogenetic Protein-2/p38 and Extracellular Signal-Regulated Kinase 1/2 Pathway in Human Osteoblast Cells

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Bmp Signaling at the Tips of Skeletal Muscles Regulates the Number of Fetal Muscle Progenitors and Satellite Cells during Development

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Retrograde BMP Signaling Regulates Trigeminal Sensory Neuron Identities and the Formation of Precise Face Maps

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Dynamic control of TGF‐β signaling and its links to the cytoskeleton

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Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?

Alarmo, E., & Kallioniemi, A. H. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0273 · Cited by 109 · see citing works

Bone morphogenetic proteins and their antagonists: current and emerging clinical uses

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Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans

Petryk, A., Graf, D., & Marcucio, R. (2014) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.161 · Cited by 108 · see citing works

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells

Valera, E., Isaacs, M. J., Kawakami, Y., Belmonte, J. C. I., & Choe, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011167 · Cited by 108 · see citing works

Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts

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BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2

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Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway

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Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells

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Bone morphogenetic protein 4—a fascinating regulator of cancer cell behavior

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Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

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Fine‐tuning BMP7 signalling in adipogenesis by UBE2O/E2‐230K‐mediated monoubiquitination of SMAD6

Zhang, X., Zhang, J., Bauer, A., Zhang, L., Selinger, D. W., Lu, C., & ten Dijke, P. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.38 · Cited by 97 · see citing works

Combinatorial Gene Therapy with BMP2/7 Enhances Cranial Bone Regeneration

Koh, J., Zhao, Z., Wang, Z., Lewis, I. S., Krebsbach, P. H., & Franceschi, R. T. (2008) · Journal of Dental Research · doi:10.1177/154405910808700906 · Cited by 100 · see citing works

The iron-regulatory hormone hepcidin: A possible therapeutic target?

Rochette, L., Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.004 · Cited by 99 · see citing works

Oxygen, a Key Factor Regulating Cell Behavior during Neurogenesis and Cerebral Diseases

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A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies

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BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

Zhu, D., Wu, J., Spee, C. K., Ryan, S. J., & Hinton, D. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809393200 · Cited by 96 · see citing works

Biomaterial challenges and approaches to stem cell use in bone reconstructive surgery

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Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future

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Bone morphogenetic proteins and their receptor signaling in prostate cancer.

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Chemically-Conjugated Bone Morphogenetic Protein-2 on Three-Dimensional Polycaprolactone Scaffolds Stimulates Osteogenic Activity in Bone Marrow Stromal Cells

Zhang, H., Migneco, F., Lin, C.-Y., & Hollister, S. J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0132 · Cited by 92 · see citing works

Umbilical Cord Wharton's Jelly: A New Potential Cell Source of Mesenchymal Stromal Cells for Bone Tissue Engineering

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ERK signaling is a central regulator for BMP-4 dependent capillary sprouting

Zhou, Q., Heinke, J., VARGAS, A., Winnik, S. H., Krauß, T., Bode, C., Patterson, C., & Moser, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.08.003 · Cited by 91 · see citing works

Narrative Review: The Enigma of Pulmonary Arterial Hypertension: New Insights from Genetic Studies

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Differential Modulation of the Oligodendrocyte Transcriptome by Sonic Hedgehog and Bone Morphogenetic Protein 4 via Opposing Effects on Histone Acetylation

Wu, M., Hernandez, M., Shen, S., Sabo, J. K., Kelkar, D., Wang, J., O’Leary, R., Phillips, G. R., Cate, H. S., & Casaccia, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4876-11.2012 · Cited by 89 · see citing works

Bmp7 Regulates the Survival, Proliferation, and Neurogenic Properties of Neural Progenitor Cells during Corticogenesis in the Mouse

Segklia, A., Seuntjens, E., Elkouris, M., Tsalavos, S., Stappers, E., Mitsiadis, T. A., Huylebroeck, D., Remboutsika, E., & Graf, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034088 · Cited by 88 · see citing works

Optimal Combination of Soluble Factors for Tissue Engineering of Permanent Cartilage from Cultured Human Chondrocytes

Liu, G., Kawaguchi, H., Ogasawara, T., Asawa, Y., Kishimoto, J., Takahashi, T., Chung, U., Yamaoka, H., Asato, H., Nakamura, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608383200 · Cited by 88 · see citing works

Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

Yang, J., Shi, P., Tu, M., Wang, Y., Liu, M., Fan, F., & Du, M. (2014) · Food Science and Human Wellness · doi:10.1016/j.fshw.2014.12.002 · Cited by 87 · see citing works

Bone Morphogenetic Protein-9 Induces Apoptosis in Prostate Cancer Cells, the Role of Prostate Apoptosis Response-4

Ye, L., Kynaston, H., & Jiang, W. G. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0171 · Cited by 87 · see citing works

Molecular therapy of the intervertebral disc

Yoon, S. T., & Patel, N. (2006) · European Spine Journal · doi:10.1007/s00586-006-0155-3 · Cited by 86 · see citing works

Regulation of systemic iron homeostasis: how the body responds to changes in iron demand

Anderson, G. J., Darshan, D., Wilkins, S. J., & Frazer, D. M. (2007) · BioMetals · doi:10.1007/s10534-006-9030-2 · Cited by 86 · see citing works

The Small Molecule Phenamil Induces Osteoblast Differentiation and Mineralization

Park, K. W., Waki, H., Kim, W.-K., Davies, B. S. J., Young, S. G., Parhami, F., & Tontonoz, P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00002-09 · Cited by 87 · see citing works

Intra-axonal Translation of SMAD1/5/8 Mediates Retrograde Regulation of Trigeminal Ganglia Subtype Specification

Ji, S., & Jaffrey, S. R. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.022 · Cited by 85 · see citing works

Betulinic Acid Stimulates the Differentiation and Mineralization of Osteoblastic MC3T3-E1 Cells: Involvement of BMP/Runx2 and β-Catenin Signals

Lo, Y., Chang, Y., Wei, B., Huang, Y., & Chiou, W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf904158k · Cited by 85 · see citing works

Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway

Niu, Y., Li, Y., Huang, H., Kong, X., Zhang, R., Liu, L., Sun, Y., Wang, T., & Mei, Q. (2011) · Phytotherapy Research · doi:10.1002/ptr.3414 · Cited by 84 · see citing works

Cross‐talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell‐specific outcomes

Herpin, A., & Cunningham, C. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05840.x · Cited by 104 · see citing works

Controlling of bone morphogenetic protein signaling

Zeng, S., Chen, J., & Shen, H. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2009.12.007 · Cited by 35 · see citing works

Bone morphogenetic proteins and signal transduction pathways

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Signaling cross-talk by bone morphogenetic proteins

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Bone morphogenetic protein receptor signal transduction in human disease

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