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The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
Open accessAbstract
Nuclear localization of the Extradenticle (EXD) and PBX1 proteins is regionally restricted during Drosophila and mammalian development. We studied the subcellular localization of EXD, PBX, and their partners Homothorax (HTH) and PREP1, in different cell contexts. HTH and PREP1 are cytoplasmic and require association with EXD/PBX for nuclear localization. EXD and PBX1 are nuclear in murine fibroblasts but not in Drosophila Schneider cells, in which they are actively exported to the cytoplasm. Coexpression of EXD/PBX with HTH/PREP1 causes nuclear localization of their heterodimers in both cell contexts. We propose that heterodimerization with HTH/PREP induces nuclear translocation of EXD and PBX1 in specific cell contexts by blocking their nuclear export.
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Cited by
THE ROLE OF KNOX GENES IN PLANT DEVELOPMENT
Hake, S., Smith, H. M. S., Holtan, H., Magnani, E., Mele, G., & Ramirez, J. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.031803.093824 · Cited by 458
Regulation of Nuclear Transport: Central Role in Development and Transformation?
Poon, I. K. H., & Jans, D. A. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00268.x · Cited by 360
Capdevila, J., Tsukui, T., Esteban, C. R., Zappavigna, V., & Belmonte, J. C. I. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80393-7 · Cited by 323
Self-citationMercader, N., Leonardo, E., Piedra, M. E., Martínez-A, C., Ángeles Ros, M., & Torres, M. (2000) · Development · doi:10.1242/dev.127.18.3961 · Cited by 321
Selleri, L., Depew, M. J., Jacobs, Y., Chanda, S. K., Tsang, K. Y., Cheah, K. S. E., Rubenstein, J. L. R., O’Gorman, S., & Cleary, M. L. (2001) · Development · doi:10.1242/dev.128.18.3543 · Cited by 297
Metadata
- Authors
- Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F., & Zappavigna, V.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-04-15
- Volume
- 13
- Issue
- 8
- Pages
- 946-953
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2096089878
- Cited by
- 236
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. https://app.cochat.ai/papers/10.1101/gad.13.8.946
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- Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F., & Zappavigna, V. (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes & Development. https://doi.org/10.1101/gad.13.8.946
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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