The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes
Open accessAbstract
Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.
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Cited by
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
del Corral, R. D., Olivera-Martinez, I., Goriely, A., Gale, E., Maden, M., & Storey, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00565-8 · Cited by 614
Functions of FGF signalling from the apical ectodermal ridge in limb development
Sun, X., Mariani, F. V., & Martin, G. R. (2002) · Nature · doi:10.1038/nature00902 · Cited by 554
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning
Mariani, F. V., Ahn, C. P., & Martin, G. R. (2008) · Nature · doi:10.1038/nature06876 · Cited by 366
Metadata
- Authors
- Mercader, N., Leonardo, E., Piedra, M. E., Martínez-A, C., Ángeles Ros, M., & Torres, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-09-15
- Volume
- 127
- Issue
- 18
- Pages
- 3961-3970
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1939881246
- Cited by
- 321
- References
- 59
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. https://app.cochat.ai/papers/10.1242/dev.127.18.3961
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- Mercader, N., Leonardo, E., Piedra, M. E., Martínez-A, C., Ángeles Ros, M., & Torres, M. (2000). Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development. https://doi.org/10.1242/dev.127.18.3961
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
