The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
Open accessAbstract
Binding of 14-3-3 proteins near the nuclear localization sequence of Xenopus Cdc25 suppresses its ability to induce entry into mitosis. We have examined the intracellular localization of green fluorescent protein (GFP)-tagged wild-type Cdc25 or a mutant (S287A) that cannot bind 14-3-3 proteins. Upon coexpression with Myc-14-3-3epsilon, GFP-Cdc25-WT was predominantly cytoplasmic, whereas GFP-Cdc25-S287A was exclusively nuclear. Leptomycin B, an inhibitor of nuclear export, elicited a prompt redistribution of GFP-Cdc25-WT to the nucleus. Mutagenesis experiments demonstrated that Cdc25 contains multiple nuclear export sequences. These studies indicate that the binding of 14-3-3 proteins and nuclear export regulate the intracellular localization of Cdc25.
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Cites
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
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CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
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CRM1 is responsible for intracellular transport mediated by the nuclear export signal
Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M., & Nishida, E. (1997) · Nature · doi:10.1038/36894 · Cited by 1,211
Nucleocytoplasmic transport: the soluble phase
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cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
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Cited by
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
Brunet, A., Kanai, F., Stehn, J., Xu, J., Sarbassova, D., Frangioni, J. V., Dalal, S. N., DeCaprio, J. A., Greenberg, M. E., & Yaffe, M. B. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112059 · Cited by 561
Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430
Self-citationRegulating mammalian checkpoints through Cdc25 inactivation
Donzelli, M., & Draetta, G. F. (2003) · EMBO reports · doi:10.1038/sj.embor.embor887 · Cited by 438
Metadata
- Authors
- Kumagai, A., & Dunphy, W. G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-05-01
- Volume
- 13
- Issue
- 9
- Pages
- 1067-1072
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2105016405
- Cited by
- 305
- References
- 31
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kumagai, A., & Dunphy, W. G. (1999). Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. Genes & Development. https://doi.org/10.1101/gad.13.9.1067
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