The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
Open accessAbstract
PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease. We used the Cre-loxP system to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice. Tie2CrePten flox/+ mice displayed enhanced tumorigenesis due to an increase in angiogenesis driven by vascular growth factors. This effect was partially dependent on the PI3K subunits p85 α and p110 γ. In vitro, Tie2CrePten flox/+ endothelial cells showed enhanced proliferation/migration. Tie2CrePten flox/flox mice died before embryonic day 11.5 (E11.5) due to bleeding and cardiac failure caused by impaired recruitment of pericytes and vascular smooth muscle cells to blood vessels, and of cardiomyocytes to the endocardium. These phenotypes depend strongly on p110 γ rather than on p85 α and were associated with decreased expression of Ang-1, VCAM-1, connexin 40, and ephrinB2 but increased expression of Ang-2, VEGF-A, VEGFR1, and VEGFR2. Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis.
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PI3K pathway alterations in cancer: variations on a theme
Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845
Endothelial to Mesenchymal Transition in Cardiovascular Disease
Kovacic, J. C., Dimmeler, S., Harvey, R. P., Finkel, T., Aikawa, E., Krenning, G., & Baker, A. H. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.089 · Cited by 631
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Islam, M. A., Xu, Y., Tao, W., Ubellacker, J. M., Lim, M., Aum, D., Lee, G. Y., Zhou, K., Zope, H., Yu, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0284-0 · Cited by 339
Metadata
- Authors
- Hamada, K., Sasaki, T., Koni, P. A., Natsui, M., Kishimoto, H., Sasaki, J., Yajima, N., Horie, Y., Hasegawa, G., Naito, M., Miyazaki, J.-I., Suda, T., Itoh, H., Nakao, K., Mak, T. W., Nakano, T., & Suzuki, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-08-17
- Volume
- 19
- Issue
- 17
- Pages
- 2054-2065
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2108270671
- Cited by
- 287
- References
- 56
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Hamada, K., Sasaki, T., Koni, P. A., Natsui, M., Kishimoto, H., Sasaki, J., Yajima, N., Horie, Y., Hasegawa, G., Naito, M., Miyazaki, J.-I., Suda, T., Itoh, H., Nakao, K., Mak, T. W., Nakano, T., & Suzuki, A. (2005). The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes & Development. https://doi.org/10.1101/gad.1308805
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