The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae
Open accessAbstract
Recent studies have revealed that transcription of noncoding, intergenic DNA is abundant among eukaryotes. However, the functions of this transcription are poorly understood. We have previously shown that in Saccharomyces cerevisiae , expression of an intergenic transcript, SRG1 , represses the transcription of the adjacent gene, SER3 , by transcription interference. We now show that SRG1 transcription is regulated by serine, thereby conferring regulation of SER3 , a serine biosynthetic gene. This regulation requires Cha4, a serine-dependent activator that binds to the SRG1 promoter and is required for SRG1 induction in the presence of serine. Furthermore, two coactivator complexes, SAGA and Swi/Snf, are also directly required for activation of SRG1 and transcription interference of SER3 . Taken together, our results elucidate a physiological role for intergenic transcription in the regulation of SER3 . Moreover, our results demonstrate a mechanism by which intergenic transcription allows activators to act indirectly as repressors.
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Cawley, S., Bekiranov, S., Ng, H. H., Kapranov, P., Sekinger, E. A., Kampa, D., Piccolboni, A., Sementchenko, V., Cheng, J., Williams, A. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00127-8 · Cited by 1,095
Henry, K. W., Wyce, A., Lo, W.-S., Duggan, L. J., Emre, N. C. T., Kao, C.-F., Pillus, L., Shilatifard, A., Osley, M. A., & Berger, S. L. (2003) · Genes & Development · doi:10.1101/gad.1144003 · Cited by 714
Using the transcriptome to annotate the genome
Saha, S., Sparks, A. B., Rago, C., Akmaev, V., Wang, C. J., Vogelstein, B., Kinzler, K. W., & Velculescu, V. E. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-508 · Cited by 630
Whole-genome expression analysis of snf/swi mutants of Saccharomyces cerevisiae
Sudarsanam, P., Iyer, V. R., Brown, P. O., & Winston, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3364 · Cited by 389
Self-citation
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MacPherson, S., Larochelle, M., & Turcotte, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-06 · Cited by 612
Antisense Transcription Controls Cell Fate in Saccharomyces cerevisiae
Hongay, C. F., Grisafi, P. L., Galitski, T., & Fink, G. R. (2006) · Cell · doi:10.1016/j.cell.2006.09.038 · Cited by 361
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Metadata
- Authors
- Martens, J. A., Wu, P.-Y. J., & Winston, F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-11-15
- Volume
- 19
- Issue
- 22
- Pages
- 2695-2704
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2141803636
- Cited by
- 240
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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