The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings
Abstract
The Drosophila Bithorax Complex encodes three well-characterized homeodomain proteins that direct segment identity, as well as several noncoding RNAs of unknown function. Here, we analyze the iab-4 locus, which produces the microRNAs iab-4-5p and iab-4-3p. iab-4 is analogous to miR-196 in vertebrate Hox clusters. Previous studies demonstrate that miR-196 interacts with the Hoxb8 3′ untranslated region. Evidence is presented that miR-iab-4-5p directly inhibits Ubx activity in vivo. Ectopic expression of mir-iab-4-5p attenuates endogenous Ubx protein accumulation and induces a classical homeotic mutant phenotype: the transformation of halteres into wings. These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of mir-iab-4 expression during development.
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Recent studies reveal diverse roles of miRNAs in the brain, including neural patterning, neural stem cell differentiation, cell type specification, synaptic plasticity, and neuropsychiatric disorders.
“Recent studies begin to reveal diverse role of miRNAs in the brain, such as in neural patterning (Ronshaugen et al., 2005), neural stem cell differentiation (Kuwabara et al., 2004), cell type specification (Poole and Hobert, 2006), synaptic plasticity (Schratt et al., 2006), and also in neuropsychiatric disorders (Shafi et al., 2010, Xu et al., 2010a).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Ronshaugen et al., 2005
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Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works
Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
Shermoen, A. W., & O'Farrell, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90182-x · Cited by 360 · see citing works
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Research works printed but not linked: 3
- Bae, E., Calhoun, V.C., Levine, M., Lewis, E.B., and Drewell, R.A. 2002. Characterization of the intergenic RNA profile at Abdominal-A and Abdominal-B in the Drosophila bithorax complex. Proc. Natl. Acad. Sci. 99: 16847-16852.
- Cumberledge, S., Zaratzian, A., and Sakonju, S. 1990. Characterization of two RNAs transcribed from the cis -regulatory region of the abd-A domain within the Drosophila bithorax complex. Proc. Natl. Acad. Sci. 87: 3259-3263.
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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605 · see citing works
The role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460 · see citing works
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works
Biemar, F., Nix, D. A., Piel, J., Peterson, B., Ronshaugen, M., Sementchenko, V., Bell, I., Manak, J. R., & Levine, M. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604484103 · Cited by 53 · see citing works
Self-citation
- Authors
- Ronshaugen, M., Biemar, F., Piel, J., Levine, M., & Lai, E. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-12-15
- Volume
- 19
- Issue
- 24
- Pages
- 2947-2952
- ISSN
- 0890-9369
- 1549-5477
- Cited by
- 146
- References
- 2
- Language
- en
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