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Cited by 534

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Wnt signaling maintains the hair-inducing activity of the dermal papilla

Open access
Kishimoto, Jiro, Burgeson, Robert E., Morgan, Bruce A.·2000·Genes & Development

Abstract

The formation of the hair follicle and its cyclical growth, quiescence, and regeneration depend on reciprocal signaling between its epidermal and dermal components. The dermal organizing center, the dermal papilla (DP), regulates development of the epidermal follicle and is dependent on signals from the epidermis for its development and maintenance. GFP specifically expressed in DP cells of a transgenic mouse was used to purify this population and study the signals required to maintain it. We demonstrate that specific Wnts, but not Sonic hedgehog (Shh), maintain anagen-phase gene expression in vitro and hair inductive activity in a skin reconstitution assay.

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Metadata

Authors
Kishimoto, J., Burgeson, R. E., & Morgan, B. A.
Venue
Genes & Development
Published
2000-05-15
Volume
14
Issue
10
Pages
1181-1185
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2102313656
Cited by
534
References
2
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Wnt signaling maintains the hair-inducing activity of the dermal papilla. https://app.cochat.ai/papers/10.1101/gad.14.10.1181
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Kishimoto, J., Burgeson, R. E., & Morgan, B. A. (2000). Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes & Development. https://doi.org/10.1101/gad.14.10.1181

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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