Wnt signaling in development and tissue homeostasis
Abstract
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
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The Wnt/β-catenin signaling pathway is considered to be one of the key pathways in development and regeneration, including cell fate, cell proliferation, cell migration and adult homeostasis.
“This pathway is considered to be one of the key pathways in development and regeneration, including cell fate, cell proliferation, cell migration and adult homeostasis [24, 25].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [24]
The Wnt/β-catenin signaling pathway is evolutionarily conserved, which means that data can be shared across cell lines.
“This may be valid as the Wnt/β-catenin signaling pathway is evolutionarily conserved [24], which means that data can be shared.”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [24]
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- Authors
- Steinhart, Z., & Angers, S.
- Affiliations
- University of Toronto (CA)
- University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2018-06-01
- Volume
- 145
- Issue
- 11
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2805309434
- Cited by
- 821
- References
- 12
- Citations by year
- 2026: 66 · 2025: 103 · 2024: 129 · 2023: 133 · 2022: 135 · 2021: 119 · 2020: 86 · 2019: 38 · 2018: 8 · 2017: 1
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Canadian Institutes of Health Research (364969)
- Canadian Cancer Society (705045)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, β-catenin, embryonic development, tissue homeostasis, stem cell self-renewal, cell proliferation, cell differentiation, cancer, regenerative medicine, intercellular communication
- MeSH terms
- Cell Self Renewal, Animals, Cell Communication, Cell Differentiation, Drosophila, Humans, Stem Cells, Cell Proliferation, Wnt Proteins, beta Catenin, Wnt Signaling Pathway
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