The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex
Open accessAbstract
We have purified and characterized a Gcn5-independent nucleosomal histone H3 HAT complex, NuA3 (Nu cleosomal A cetyltransferase of histone H 3). Peptide sequencing of proteins from the purified NuA3 complex identified Sas3 as the catalytic HAT subunit of the complex. Sas3 is the yeast homolog of the human MOZ oncogene. Sas3 is required for both the HAT activity and the integrity of the NuA3 complex. In addition, NuA3 contains the TBP- associated factor, yTAF II 30, which is also a component of the TFIID, TFIIF, and SWI/SNF complexes. Sas3 mediates interaction of the NuA3 complex with Spt16 both in vivo and in vitro. Spt16 functions as a component of the yeast CP (Cdc68/Pob3) and mammalian FACT (fa cilitates c hromatin t ranscription) complexes, which are involved in transcription elongation and DNA replication. This interaction suggests that the NuA3 complex might function in concert with FACT–CP to stimulate transcription or replication elongation through nucleosomes by providing a coupled acetyltransferase activity.
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Cites
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
Krebs, J. E., Kuo, M.-H., Allis, C. D., & Peterson, C. L. (1999) · Genes & Development · doi:10.1101/gad.13.11.1412 · Cited by 275
Wang, L., Liu, L., & Berger, S. L. (1998) · Genes & Development · doi:10.1101/gad.12.5.640 · Cited by 232
Cited by
Functions of Site-Specific Histone Acetylation and Deacetylation
Shahbazian, M. D., & Grunstein, M. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052705.162114 · Cited by 1,635
Henry, K. W., Wyce, A., Lo, W.-S., Duggan, L. J., Emre, N. C. T., Kao, C.-F., Pillus, L., Shilatifard, A., Osley, M. A., & Berger, S. L. (2003) · Genes & Development · doi:10.1101/gad.1144003 · Cited by 714
Elongation by RNA polymerase II: the short and long of it
Sims, R. J., Belotserkovskaya, R., & Reinberg, D. (2004) · Genes & Development · doi:10.1101/gad.1235904 · Cited by 709
Transcriptional coactivator complexes.
Näär, A. M., Lemon, B. D., & Tjian, R. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.475 · Cited by 571
The diverse functions of histone acetyltransferase complexes
Carrozza, M. J., Utley, R. T., Workman, J. L., & Côté, J. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00115-x · Cited by 487
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Metadata
- Authors
- John, S., Howe, L., Tafrov, S. T., Grant, P. A., Sternglanz, R., & Workman, J. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-05-15
- Volume
- 14
- Issue
- 10
- Pages
- 1196-1208
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2106317558
- Cited by
- 226
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex. https://app.cochat.ai/papers/10.1101/gad.14.10.1196
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- John, S., Howe, L., Tafrov, S. T., Grant, P. A., Sternglanz, R., & Workman, J. L. (2000). The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex. Genes & Development. https://doi.org/10.1101/gad.14.10.1196
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