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The diverse functions of histone acetyltransferase complexes
Abstract
Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle progression. The high conservation of the acetyltransferase complexes and their functions illustrates their central role in cell growth and development.
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Tier 2 captures full spectrum biological surveillance looking at the entire human biological condition.
“Tier 2 captures full spectrum biological surveillance looking at the entire human biological condition”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [33]
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Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
McMahon, S. B., Wood, M. A., & Cole, M. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.556-562.2000 · Cited by 494
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Balasubramanian, R., Pray-Grant, M. G., Selleck, W., Grant, P. A., & Tan, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110849200 · Cited by 233
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Metadata
- Authors
- Carrozza, M. J., Utley, R. T., Workman, J. L., & Côté, J.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 19
- Issue
- 6
- Pages
- 321-329
- ISSN
- 0168-9525
- Cited by
- 487
- References
- 4
- Language
- en
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