The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An essential role in liver development for transcription factor XBP-1
Open accessAbstract
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP-1 in the liver were identified as αFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
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Metadata
- Authors
- Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., & Glimcher, L. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-01-15
- Volume
- 14
- Issue
- 2
- Pages
- 152-157
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2161083011
- Cited by
- 516
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H. F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., & Glimcher, L. H. (2000). An essential role in liver development for transcription factor XBP-1. Genes & Development. https://doi.org/10.1101/gad.14.2.152
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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