The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ku complex interacts with and stimulates the Werner protein
Open accessAbstract
Werner syndrome (WS) is the hallmark premature aging disorder in which affected humans appear older than their chronological age. The protein WRNp, defective in WS, has helicase function, DNA-dependent ATPase, and exonuclease activity. Although WRNp functions in nucleic acid metabolism, there is little or no information about the pathways or protein interactions in which it participates. Here we identify Ku70 and Ku86 as proteins that interact with WRNp. Although Ku proteins had no effect on ATPase or helicase activity, they strongly stimulated specific exonuclease activity. These results suggest that WRNp and the Ku complex participate in a common DNA metabolic pathway.
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Citations
Cites
The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo
Cooper, M. P., Balajee, A. S., & Bohr, V. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.7.2119 · Cited by 80
Self-citation
Cited by
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
Aging and Genome Maintenance: Lessons from the Mouse?
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553
Johnson, F. B., Marciniak, R. A., McVey, M., Stewart, S. A., Hahn, W. C., & Guarente, L. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.905 · Cited by 269
Taylor, T. J., & Knipe, D. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5856-5866.2004 · Cited by 229
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
Stinson, B. M., & Loparo, J. J. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080320-110356 · Cited by 223
Metadata
- Authors
- Cooper, M. P., Machwe, A., Orren, D. K., Brosh, R. M., Ramsden, D., & Bohr, V. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-04-15
- Volume
- 14
- Issue
- 8
- Pages
- 907-912
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1940074648
- Cited by
- 320
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Cooper, M. P., Machwe, A., Orren, D. K., Brosh, R. M., Ramsden, D., & Bohr, V. A. (2000). Ku complex interacts with and stimulates the Werner protein. Genes & Development. https://doi.org/10.1101/gad.14.8.907
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
