The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis
Open accessAbstract
The association of transcriptional coactivators with sequence-specific DNA-binding proteins provides versatility and specificity to gene regulation and expands the regulatory potential of individual cis-regulatory DNA sequences. Members of the myocardin family of coactivators activate genes involved in cell proliferation, migration, and myogenesis by associating with serum response factor (SRF). The partnership of myocardin family members and SRF also controls genes encoding components of the actin cytoskeleton and confers responsiveness to extracellular growth signals and intracellular changes in the cytoskeleton, thereby creating a transcriptional–cytoskeletal regulatory circuit. These functions are reflected in defects in smooth muscle differentiation and function in mice with mutations in myocardin family members. This article reviews the functions and mechanisms of action of the myocardin family of coactivators and the physiological significance of transcriptional coactivation in the context of signal-dependent and cell-type-specific gene regulation.
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Cites
Biological control through regulated transcriptional coactivators
Spiegelman, B. M., & Heinrich, R. (2004) · Cell · doi:10.1016/j.cell.2004.09.037 · Cited by 377
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Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958
Self-citationGenome-wide analysis of transcription factor binding sites based on ChIP-Seq data
Valouev, A., Johnson, D. S., Sundquist, A., Medina, C., Anton, E., Batzoglou, S., Myers, R. M., & Sidow, A. (2008) · Nature Methods · doi:10.1038/nmeth.1246 · Cited by 695
Xin, M., Small, E. M., Sutherland, L. B., Qi, X., McAnally, J., Plato, C. F., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2009) · Genes & Development · doi:10.1101/gad.1842409 · Cited by 649
Self-citationNuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL
Vartiainen, M. K., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 622
Metadata
- Authors
- Pipes, G. C. T., Creemers, E. E., & Olson, E. N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-06-15
- Volume
- 20
- Issue
- 12
- Pages
- 1545-1556
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2143850042
- Cited by
- 475
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Pipes, G. C. T., Creemers, E. E., & Olson, E. N. (2006). The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes & Development. https://doi.org/10.1101/gad.1428006
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