The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL
Abstract
Actin, which is best known as a cytoskeletal component, also participates in the control of gene expression. We report a function of nuclear actin in the regulation of MAL, a coactivator of the transcription factor serum response factor (SRF). MAL, which binds monomeric actin, is cytoplasmic in many cells but accumulates in the nucleus upon serum-induced actin polymerization. MAL rapidly shuttles between cytoplasm and nucleus in unstimulated cells. Serum stimulation effectively blocks MAL nuclear export, which requires MAL-actin interaction. Nuclear MAL binds SRF target genes but remains inactive unless actin binding is disrupted. Fluorescence resonance energy transfer analysis demonstrates that the MAL-actin interaction responds to extracellular signals. Serum-induced signaling is thus communicated to nuclear actin to control a transcriptional regulator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells
Patterson, G. H., & Lippincott-Schwartz, J. (2002) · Science · doi:10.1126/science.1074952 · Cited by 1,612
Actin dynamics control SRF activity by regulation of its coactivator MAL
Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327
Self-citationResonance Energy Transfer: Methods and Applications
Wu, P. G., & Brand, L. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1134 · Cited by 1,277
Development and Use of Fluorescent Protein Markers in Living Cells
Lippincott-Schwartz, J., & Patterson, G. H. (2003) · Science · doi:10.1126/science.1082520 · Cited by 992
Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics
Sotiropoulos, A., Gineitis, D., Copeland, J., & Treisman, R. (1999) · Cell · doi:10.1016/s0092-8674(00)81011-9 · Cited by 655
Self-citationPipes, G. C. T., Creemers, E. E., & Olson, E. N. (2006) · Genes & Development · doi:10.1101/gad.1428006 · Cited by 475
Exportin 6: a novel nuclear export receptor that is specific for profilin{middle dot}actin complexes
Stuven, T. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg565 · Cited by 338
Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W., & Prywes, R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6597-6608.2003 · Cited by 289
Posern, G., Sotiropoulos, A., & Treisman, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-05-0068 · Cited by 274
Self-citationActin in transcription and transcription regulation
Miralles, F., & Visa, N. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.04.009 · Cited by 151
Cited by
Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Linking actin dynamics and gene transcription to drive cellular motile functions
Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958
Micropatterning as a tool to decipher cell morphogenesis and functions
Théry, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.075150 · Cited by 730
The myofibroblast: Paradigm for a mechanically active cell
Hinz, B. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 698
Metadata
- Authors
- Vartiainen, M. K., Guettler, S., Larijani, B., & Treisman, R.
- Venue
- Science
- Published
- 2007-06-22
- Volume
- 316
- Issue
- 5832
- Pages
- 1749-1752
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967487834
- Cited by
- 622
- References
- 12
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL. https://app.cochat.ai/papers/10.1126/science.1141084
- The paper
- Vartiainen, M. K., Guettler, S., Larijani, B., & Treisman, R. (2007). Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL. Science. https://doi.org/10.1126/science.1141084
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
