The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
Open accessAbstract
Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells (SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator, myocardin, play a central role in the control of smooth muscle phenotypes by regulating the expression of cytoskeletal genes. We show that SRF and myocardin regulate a cardiovascular-specific microRNA (miRNA) cluster encoding miR-143 and miR-145. To assess the functions of these miRNAs in vivo, we systematically deleted them singly and in combination in mice. Mice lacking both miR-143 and miR-145 are viable and do not display overt abnormalities in smooth muscle differentiation, although they show a significant reduction in blood pressure due to reduced vascular tone. Remarkably, however, neointima formation in response to vascular injury is profoundly impeded in mice lacking these miRNAs, due to disarray of actin stress fibers and diminished migratory activity of SMCs. These abnormalities reflect the regulation of a cadre of modulators of SRF activity and actin dynamics by miR-143 and miR-145. Thus, miR-143 and miR-145 act as integral components of the regulatory network whereby SRF controls cytoskeletal remodeling and phenotypic switching of SMCs during vascular disease.
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Self-citationDysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
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Self-citationThe Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
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Self-citationmiR-145 and miR-143 regulate smooth muscle cell fate and plasticity
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Self-citationAtheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
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Metadata
- Authors
- Xin, M., Small, E. M., Sutherland, L. B., Qi, X., McAnally, J., Plato, C. F., Richardson, J. A., Bassel-Duby, R., & Olson, E. N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-08-31
- Volume
- 23
- Issue
- 18
- Pages
- 2166-2178
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2171559697
- Cited by
- 649
- References
- 51
- Type
- posted content
- Language
- en
- Open access
- diamond
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