The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sox2 is required for development of taste bud sensory cells
Open accessAbstract
Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2 EGFP/LP embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells inhibits differentiation of filiform keratinocytes. Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.
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Cites
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Cited by
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N., & Hochedlinger, K. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.001 · Cited by 768
Sox proteins: regulators of cell fate specification and differentiation
Kamachi, Y., & Kondoh, H. (2013) · Development · doi:10.1242/dev.091793 · Cited by 572
Grigoryan, T., Wend, P., Klaus, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 560
Tridimensional Visualization and Analysis of Early Human Development
Belle, M., Godefroy, D., Couly, G., Malone, S. A., Collier, F., Giacobini, P., & Chédotal, A. (2017) · Cell · doi:10.1016/j.cell.2017.03.008 · Cited by 346
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
Metadata
- Authors
- Okubo, T., Pevny, L. H., & Hogan, B. L. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-10-01
- Volume
- 20
- Issue
- 19
- Pages
- 2654-2659
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W4298370949
- Cited by
- 199
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Okubo, T., Pevny, L. H., & Hogan, B. L. M. (2006). Sox2 is required for development of taste bud sensory cells. Genes & Development. https://doi.org/10.1101/gad.1457106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
