Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Open accessAbstract
The dermal papilla comprises the specialised mesenchymal cells at the base of the hair follicle. Communication between dermal papilla cells and the overlying epithelium is essential for differentiation of the hair follicle lineages. We report that Sox2 is expressed in all dermal papillae at E16.5,but from E18.5 onwards expression is confined to a subset of dermal papillae. In postnatal skin, Sox2 is only expressed in the dermal papillae of guard/awl/auchene follicles, whereas CD133 is expressed both in guard/awl/auchene and in zigzag dermal papillae. Using transgenic mice that express GFP under the control of the Sox2 promoter, we isolated Sox2+ (GFP+) CD133+ cells and compared them with Sox2- (GFP-) CD133+ dermal papilla cells. In addition to the `core' dermal papilla gene signature, each subpopulation expressed distinct sets of genes. GFP+CD133+ cells had upregulated Wnt, FGF and BMP pathways and expressed neural crest markers. In GFP- CD133+ cells,the hedgehog, IGF, Notch and integrin pathways were prominent. In skin reconstitution assays, hair follicles failed to form when dermis was depleted of both GFP+ CD133+ and GFP-CD133+ cells. In the absence of GFP+ CD133+cells, awl/auchene hairs failed to form and only zigzag hairs were found. We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types.
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SOX2 was expressed in every dermal papilla cell cluster examined.
“The transcription factor SOX2 was expressed in every dermal papilla (DP) cell cluster examined (Fig. 1i–l, Supplementary Video 1, 2), consistent with human foetal HFs and mouse guard, awl, and auchene HFs17.”
From Hair-bearing human skin generated entirely from pluripotent stem cells (2020) · cites this paper as [17]
The citation supports the comparison with mouse guard, awl and auchene follicles: the section ‘Sox2 is expressed in guard/awl/auchene dermal papillae but not in zigzag dermal papillae’ reports Sox2 expression in those follicle types. Our copy does not report the claimed comparison with human foetal hair follicles. The statement that every cluster in the citing authors’ examination expressed SOX2 refers to their own observations, not a finding attributed to this source. (LLM, conf=0.85)
Experimental — accuracy not yet measuredSOX2 is a key protein in the dermal papilla for the development of HFs in mammals.
“SOX2 is a key protein in the dermal papilla for the development of HFs in mammals [21].”
From The empowering influence of air-liquid interface culture on skin organoid hair follicle development (2025) · cites this paper as [21]
The section on Sox2 expression in the dermal papilla reports Sox2 in developing mouse hair follicles, and the paper’s opening summary reports that Sox2-positive dermal papilla cells specify particular follicle types. But the reconstitution experiment removed Sox2-positive cells, not Sox2 protein itself; zigzag follicles still formed. The paper therefore does not establish that SOX2 protein is broadly required for hair-follicle development in mammals. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe bulb-like structures are reminiscent of nascent guard, awl, or auchene hair follicles.
“We discovered that these structures were extensions of the KRT5+ epidermis and were associated with SOX2+ dermal papilla (DP)-like cells (Figure 1C, D), reminiscent of nascent guard, awl, or auchene HFs (Driskell et al., 2009; Lesko et al., 2013).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Driskell et al., 2009
The majority of SG-like structures observed in the skin organoids were bifurcates, reminiscent of guard hairs.
“The majority of SG-like structures observed in the skin organoids were bifurcates, reminiscence of guard hairs (Driskell et al., 2009).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Driskell et al., 2009
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Cites
Out of Eden: Stem Cells and Their Niches
Watt, F. M., & Hogan, A. B. L. M. (2000) · Science · doi:10.1126/science.287.5457.1427 · Cited by 1,754 · see citing works
Self-citationIsolation of multipotent adult stem cells from the dermis of mammalian skin
Toma, J. G., Akhavan, M., Fernandes, K. J. L., Barnabé‐Heider, F., Sadikot, A. F., Kaplan, D. R., & Miller, F. D. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-778 · Cited by 1,593 · see citing works
Müller-Röver, S., Foitzik, K., Paus, R., Handjiski, B., van der Veen, C., Eichmüller, S., McKay, I. A., & Stenn, K. S. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01377.x · Cited by 1,375 · see citing works
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344 · see citing works
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works
Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00208-2 · Cited by 1,043 · see citing works
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967 · see citing works
How is pluripotency determined and maintained?
Niwa, H. (2007) · Development · doi:10.1242/dev.02787 · Cited by 778 · see citing works
Morrison, S. J., White, P. M., Zock, C., & Anderson, D. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80583-8 · Cited by 749 · see citing works
A dermal niche for multipotent adult skin-derived precursor cells
Fernandes, K. J. L., McKenzie, I. A., Mill, P., Smith, K. M., Akhavan, M., Barnabé‐Heider, F., Biernaskie, J. A., Junek, A., Kobayashi, N., Toma, J. G., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1181 · Cited by 733 · see citing works
Induction of hair growth by implantation of cultured dermal papilla cells
Jahoda, C. A. B., Horne, K. A., & OLIVER, R. F. (1984) · Nature · doi:10.1038/311560a0 · Cited by 646 · see citing works
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589 · see citing works
SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells.
Kim, J., Lo, L., Dormand, E., & Anderson, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00163-6 · Cited by 584 · see citing works
SOX2 is a dose-dependent regulator of retinal neural progenitor competencePreprint
Taranova, O., Magness, S. T., Fagan, B. M., Wu, Y., Surzenko, N., Hutton, S. R., & Pevny, L. H. (2006) · Genes & Development · doi:10.1101/gad.1407906 · Cited by 554 · see citing works
van der Veen, C., Handjiski, B., Paus, R., Müller-Röver, S., Maurer, M., Eichmüller, S., Ling, G., Hofmann, U., Foitzik, K., & Mecklenburg, L. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00740.x · Cited by 553 · see citing works
Molecular principles of hair follicle induction and morphogenesis
Schmidt‐Ullrich, R., & Paus, R. (2005) · BioEssays · doi:10.1002/bies.20184 · Cited by 549 · see citing works
Sox2 is required for sensory organ development in the mammalian inner ear
Kiernan, A. E., Pelling, A. L., Leung, K. K. H., Tang, A. S. P., Bell, D. M., TEASE, C., Lovell-Badge, R. H., Steel, K. P., & Cheah, K. S. E. (2005) · Nature · doi:10.1038/nature03487 · Cited by 538 · see citing works
Wnt signaling maintains the hair-inducing activity of the dermal papillaPreprint
Kishimoto, J., Burgeson, R. E., & Morgan, B. A. (2000) · Genes & Development · doi:10.1101/gad.14.10.1181 · Cited by 535 · see citing works
Que, J., Okubo, T., Goldenring, J. R., Nam, K.-T., Kurotani, R., Morrisey, E. E., Taranova, O., Pevny, L., & Hogan, B. L. M. (2007) · Development · doi:10.1242/dev.003855 · Cited by 511 · see citing works
Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs
Rinn, J. L., Bondre, C., Gladstone, H. B., Brown, P. O., & Chang, H. Y. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020119 · Cited by 505 · see citing works
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489 · see citing works
Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle
Rendl, M., Lewis, L. E., & Fuchs, E. V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030331 · Cited by 476 · see citing works
From stem cells to neurons and glia: a Soxist's view of neural development
Wegner, M., & Stolt, C. C. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.08.008 · Cited by 426 · see citing works
BMP signaling in dermal papilla cells is required for their hair follicle-inductive propertiesPreprint
Rendl, M., Polak, L., & Fuchs, E. V. (2008) · Genes & Development · doi:10.1101/gad.1614408 · Cited by 423 · see citing works
Joseph, N. M., Mukouyama, Y., Mosher, J. T., Jaegle, M., Crone, S. A., Dormand, E.-L., Lee, K., Meijer, D., Anderson, D. J., & Morrison, S. J. (2004) · Development · doi:10.1242/dev.01429 · Cited by 339 · see citing works
Sneddon, J. B., Zhen, H. H., Montgomery, K. D., van de Rijn, M., Tward, A. D., West, R. B., Gladstone, H. B., Chang, H. Y., Morganroth, G. S., Oro, A. E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606857103 · Cited by 299 · see citing works
Epidermal Notch signalling: differentiation, cancer and adhesion
Watt, F. M., Estrach, S., & Ambler, C. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.010 · Cited by 294 · see citing works
Self-citationElliott, K., Messenger, A. G., & Stephenson, T. J. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00797.x · Cited by 251 · see citing works
Noggin is required for induction of the hair follicle growth phase in postnatal skin
Botchkarev, V. A., Botchkareva, N. V., Nakamura, M., Huber, O., Funa, K., Lauster, R., Paus, R., & Gilchrest, B. A. (2001) · The FASEB Journal · doi:10.1096/fj.01-0207com · Cited by 251 · see citing works
Silva-Vargas, V., Celso, C. L., Giangreco, A., Ofstad, T. A., Prowse, D. M., Braun, K. M., & Watt, F. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.013 · Cited by 237 · see citing works
Self-citationMore than one way to skin . . .
Fuchs, E., & Horsley, V. (2008) · Genes & Development · doi:10.1101/gad.1645908 · Cited by 224 · see citing works
Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome
Williamson, K. A., Hever, A. M., Rainger, J., Rogers, R. C., Magee, A. C., Fiedler, Z., Keng, W. T., Sharkey, F. H., McGill, N. I., Hill, C. J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl064 · Cited by 223 · see citing works
Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice
Pennisi, D. J., Gardner, J. M., Chambers, D. M., Hosking, B. M., Peters, J., Muscat, G. E. O., Abbott, C. M., & Koopman, P. A. (2000) · Nature Genetics · doi:10.1038/74301 · Cited by 222 · see citing works
Ectodysplasin signaling in development.
Mikkola, M. L., & Thesleff, I. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00020-0 · Cited by 217 · see citing works
Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells
D’Amour, K. A., & Gage, F. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834200100 · Cited by 210 · see citing works
A dermal HOX transcriptional program regulates site-specific epidermal fatePreprint
Rinn, J. L., Wang, J. K., Allen, N., Brugmann, S. A., Mikels, A. J., Liu, H., Ridky, T. W., Stadler, H. S., Nusse, R., Helms, J. A., et al. (2008) · Genes & Development · doi:10.1101/gad.1610508 · Cited by 201 · see citing works
Sox2 is required for development of taste bud sensory cellsPreprint
Okubo, T., Pevny, L. H., & Hogan, B. L. M. (2006) · Genes & Development · doi:10.1101/gad.1457106 · Cited by 199 · see citing works
Evo-Devo of amniote integuments and appendages.
Wu, P., Hou, L., Plikus, M. V., Hughes, M. W., Scehnet, J. S., Suksaweang, S., Widelitz, R. B., Jiang, T., & Chuong, C. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15272390 · Cited by 199 · see citing works
Rosenquist, T. A., & Martin, G. R. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199604)205:4 · Cited by 196 · see citing works
Epidermal stem cells: an update
Watt, F. M., Celso, C. L., & Silva-Vargas, V. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.006 · Cited by 193 · see citing works
Self-citationEvo-Devo of amniote integuments and appendages
Wu, P., Hou, L., Plikus, M. V., Hughes, M. W., Scehnet, J. S., Suksaweang, S., Widelitz, R. B., Jiang, T. X., & Chuong, C. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041825pw · Cited by 181 · see citing works
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning
Petiot, A., Conti, F. J. A., Grose, R. P., Revest, J., Hodivala‐Dilke, K., & Dickson, C. (2003) · Development · doi:10.1242/dev.00788 · Cited by 176 · see citing works
Kawano, M., Komi-Kuramochi, A., Asada, M., Suzuki, M., Oki, J., Jiang, J., & Imamura, T. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23693.x · Cited by 147 · see citing works
Shimizu, H., & Morgan, B. A. (2004) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2004.22224.x · Cited by 145 · see citing works
Botchkarev, V. A., Botchkareva, N. V., Sharov, A. A., Gilchrest, B. A., Funa, K., & Huber, O. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01645.x · Cited by 145 · see citing works
The adult hair follicle: Cradle for pluripotent neural crest stem cells
Sieber‐Blum, M., & Grim, M. (2004) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20008 · Cited by 140 · see citing works
Jahoda, C. A. B. (1992) · Development · doi:10.1242/dev.115.4.1103 · Cited by 125 · see citing works
The serine protease Corin is a novel modifier of the agouti pathway
Enshell‐Seijffers, D., Lindon, C., & Morgan, B. A. (2007) · Development · doi:10.1242/dev.011031 · Cited by 122 · see citing works
Handbook of Mouse Mutations with Skin and Hair Abnormalities
Sundberg, J. P. (2020) · CRC Press eBooks · doi:10.1201/9781003068952 · Cited by 121 · see citing works
Determination of hair structure and shape
Schlake, T. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.01.005 · Cited by 117 · see citing works
The stem cell compartment in human interfollicular epidermis
Watt, F. M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(02)00003-8 · Cited by 113 · see citing works
Self-citationHair follicle regeneration using grafted rodent and human cells
Ehama, R., Ishimatsu-Tsuji, Y., Iriyama, S., Ideta, R., Soma, T., Yano, K., Kawasaki, C., Suzuki, S., Shirakata, Y., Hashimoto, K., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700823 · Cited by 110 · see citing works
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
Lorenz, K., Grashoff, C., Torka, R., Sakai, T., Langbein, L., Bloch, W., Aumailley, M., & Fässler, R. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608125 · Cited by 108 · see citing works
Guidance cues involved in the development of the peripheral autonomic nervous system
Young, H. M., Anderson, R. B., & Anderson, C. R. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.02.008 · Cited by 106 · see citing works
The genetics and development of ‘crinkled’, a new mutant in the house mouse
Falconer, D. S., Fraser, A. S., & King, J. W. B. (1951) · Journal of Genetics · doi:10.1007/bf02996227 · Cited by 103 · see citing works
Isolation of Murine Hair-Inducing Cells Using the Cell Surface Marker Prominin-1/CD133
Ito, Y., Hamazaki, T. S., Ohnuma, K., Tamaki, K., Asashima, M., & Okochi, H. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700665 · Cited by 102 · see citing works
Sharov, A. A., Sharova, T. Y., Mardaryev, A. N., di Vignano, A. T., Atoyan, R., Weiner, L., Yang, S., Brissette, J. L., Dotto, G. P., & Botchkarev, V. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608899103 · Cited by 100 · see citing works
A Systems Biology Approach to Anatomic Diversity of Skin
Rinn, J. L., Wang, J. K., Liu, H., Montgomery, K. D., van de Rijn, M., & Chang, H. Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700986 · Cited by 94 · see citing works
Restoration of hair growth by surgical implantation of follicular dermal sheath
Horne, K. A., & Jahoda, C. A. B. (1992) · Development · doi:10.1242/dev.116.3.563 · Cited by 84 · see citing works
Sox18 mutations in the ragged mouse alleles ragged‐like and opossum
James, K. M., Hosking, B. M., Gardner, J. M., Muscat, G. E. O., & Koopman, P. A. (2003) · genesis · doi:10.1002/gene.10190 · Cited by 63 · see citing works
Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis
Ellis, T., Smyth, I., Riley, E., Bowles, J., Adolphe, C., Rothnagel, J. A., Wicking, C., & Wainwright, B. J. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00394-4 · Cited by 53 · see citing works
Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs
Schlake, T. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.04.012 · Cited by 41 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291 · see citing works
Self-citationFibroblasts: Origins, definitions, and functions in health and disease
Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,162 · see citing works
Self-citationThe Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915 · see citing works
The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Li, L., Rutlin, M. L., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., Jankowski, M. P., Luo, W., Heintz, N., Koerber, H. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.027 · Cited by 760 · see citing works
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R. T., Sengupta, S., Seandel, M., Geijsen, N., & Hochedlinger, K. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.09.001 · Cited by 754 · see citing works
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
Boumahdi, S., Driessens, G., Lapouge, G., Rorive, S., Nassar, D., Mercier, M. L., Delatte, B., Caauwe, A., Lenglez, S., Nkusi, E., et al. (2014) · Nature · doi:10.1038/nature13305 · Cited by 657 · see citing works
Regeneration of fat cells from myofibroblasts during wound healing
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584 · see citing works
Sox proteins: regulators of cell fate specification and differentiation
Kamachi, Y., & Kondoh, H. (2013) · Development · doi:10.1242/dev.091793 · Cited by 568 · see citing works
Skin shedding and tissue regeneration in African spiny mice (Acomys)
Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., & Maden, M. (2012) · Nature · doi:10.1038/nature11499 · Cited by 556 · see citing works
Fibroblast heterogeneity: implications for human disease
Lynch, M. D., & Watt, F. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93555 · Cited by 490 · see citing works
Self-citationHair-bearing human skin generated entirely from pluripotent stem cells
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., et al. (2020) · Nature · doi:10.1038/s41586-020-2352-3 · Cited by 487 · see citing works
Philippeos, C., Telerman, S. B., Oulès, B., Pisco, A. O., Shaw, T. J., Elgueta, R., Lombardi, G., Driskell, R. R., Soldin, M., Lynch, M. D., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.01.016 · Cited by 454 · see citing works
Self-citationBrownell, I., Guevara, E., Bai, C. B., Loomis, C. A., & Joyner, A. L. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.021 · Cited by 451 · see citing works
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Driskell, R. R., Clavel, C., Rendl, M., & Watt, F. M. (2011) · Journal of Cell Science · doi:10.1242/jcs.082446 · Cited by 450 · see citing works
Self-citationSkin tissue regeneration for burn injury
Shpichka, A. I., Butnaru, D. V., Bezrukov, E. A., Sukhanov, R. B., Atala, A., Бурдуковский, В. Ф., Zhang, Y., & Timashev, P. S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1203-3 · Cited by 431 · see citing works
Review of hair follicle dermal cells
Yang, C.-C., & Cotsarelis, G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.11.005 · Cited by 418 · see citing works
Understanding fibroblast heterogeneity in the skin
Driskell, R. R., & Watt, F. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.001 · Cited by 406 · see citing works
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Sennett, R., & Rendl, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 387 · see citing works
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Hsu, Y., Li, L., & Fuchs, E. V. (2014) · Cell · doi:10.1016/j.cell.2014.02.057 · Cited by 379 · see citing works
SOX2 in development and cancer biology
Novak, D., Hüser, L., Elton, J. J., Umansky, V., Altevogt, P., & Utikal, J. S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.007 · Cited by 369 · see citing works
SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
Biernaskie, J., Paris, M., Morozova, O., Fagan, B. M., Marra, M. A., Pevny, L., & Miller, F. D. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.10.019 · Cited by 357 · see citing works
The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche
Fujiwara, H., Ferreira, M. M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., & Watt, F. M. (2011) · Cell · doi:10.1016/j.cell.2011.01.014 · Cited by 317 · see citing works
Self-citationFibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
Sriram, G., Bigliardi, P. L., & Bigliardi‐Qi, M. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.08.001 · Cited by 269 · see citing works
Chi, W., Wu, E., & Morgan, B. A. (2013) · Development · doi:10.1242/dev.090662 · Cited by 269 · see citing works
Rahmani, W. M., Abbasi, S., Hagner, A., Raharjo, E., Kumar, R., Hotta, A., Magness, S. T., METZGER, D., & Biernaskie, J. A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.10.022 · Cited by 263 · see citing works
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260 · see citing works
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches
Toyoshima, K.-E., Asakawa, K., Ishibashi, N., Toki, H., Ogawa, M., Hasegawa, T., Irié, T., Tachikawa, T., Sato, A., Takeda, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms1784 · Cited by 250 · see citing works
Morgan, B. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015180 · Cited by 243 · see citing works
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
Harel, S., Higgins, C. A., Cerise, J. E., Dai, Z., Chen, J. C., Clynes, R., & Christiano, A. M. (2015) · Science Advances · doi:10.1126/sciadv.1500973 · Cited by 238 · see citing works
Sennett, R., Wang, Z., Rezza, A., Grisanti, L., Roitershtein, N., Sicchio, C., Mok, K. W., Heitman, N. J., Clavel, C., Ma’ayan, A., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.023 · Cited by 211 · see citing works
Functional characterization of SOX2 as an anticancer target
Zhang, S., Xiong, X., & Sun, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00242-3 · Cited by 208 · see citing works
Rezza, A., Wang, Z., Sennett, R., Qiao, W., Wang, D., Heitman, N., Mok, K. W., Clavel, C., Yi, R., Zandstra, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.078 · Cited by 197 · see citing works
SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond
Schaefer, T., & Lengerke, C. (2019) · Oncogene · doi:10.1038/s41388-019-0997-x · Cited by 197 · see citing works
Kozłowska, U., Krawczenko, A., Futoma, K., Jurek, T., Rorat, M., Patrzałek, D., & Klimczak, A. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i6.347 · Cited by 188 · see citing works
Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids
Lee, J., Bӧscke, R., Tang, P.-C., Hartman, B. H., Heller, S., & Koehler, K. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.007 · Cited by 187 · see citing works
Hairy tale of signaling in hair follicle development and cycling
Lee, J., & Tumbar, T. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.003 · Cited by 188 · see citing works
Roudaut, Y., Lonigro, A., Coste, B., Hao, J., Delmas, P., & Crest, M. (2012) · Channels · doi:10.4161/chan.22213 · Cited by 188 · see citing works
Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loopPreprint
Woo, W., Zhen, H. H., & Oro, A. E. (2012) · Genes & Development · doi:10.1101/gad.187401.112 · Cited by 183 · see citing works
Jensen, K. B., Driskell, R. R., & Watt, F. M. (2010) · Nature Protocols · doi:10.1038/nprot.2010.39 · Cited by 178 · see citing works
Self-citationCorticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Choi, S., Zhang, B., Ma, S., Gonzalez-Celeiro, M., Stein, D., Jin, X., Kim, S. T., Kang, Y.-L., Besnard, A., Rezza, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03417-2 · Cited by 177 · see citing works
Restoration of the intrinsic properties of human dermal papilla in vitro
Ohyama, M., Kobayashi, T., Sasaki, T., Shimizu, A., & Amagai, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.105700 · Cited by 162 · see citing works
Fgf20 governs formation of primary and secondary dermal condensations in developing hair folliclesPreprint
Huh, S., Närhi, K. M., Lindfors, P. H., Häärä, O., Yang, L. M., Ornitz, D. M., & Mikkola, M. L. (2013) · Genes & Development · doi:10.1101/gad.198945.112 · Cited by 155 · see citing works
Clavel, C., Grisanti, L., Zemla, R., Rezza, A., Barros, R., Sennett, R., Mazloom, A. R., Chung, C., Cai, X., Cai, C., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.013 · Cited by 156 · see citing works
Stem cell dynamics in the hair follicle niche
Rompolas, P., & Greco, V. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.12.005 · Cited by 159 · see citing works
Hierarchical patterning modes orchestrate hair follicle morphogenesis
Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., Johansson, J. A., Ford, M. J., Jahoda, C. A. B., Klika, V., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2002117 · Cited by 155 · see citing works
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
Solanas, G., & Benitah, S. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3675 · Cited by 152 · see citing works
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin
Collins, C. A., Kretzschmar, K., & Watt, F. M. (2011) · Development · doi:10.1242/dev.064592 · Cited by 152 · see citing works
Self-citationWnt/β-catenin signaling in adult mammalian epithelial stem cells
Kretzschmar, K., & Clevers, H. C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.015 · Cited by 144 · see citing works
An updated classification of hair follicle morphogenesis
Saxena, N., Mok, K., & Rendl, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13913 · Cited by 147 · see citing works
Oct4 and Klf4 Reprogram Dermal Papilla Cells into Induced Pluripotent Stem Cells
Tsai, S., Clavel, C., Kim, S., Ang, Y.-S., Grisanti, L., Lee, D., Kelley, K. A., & Rendl, M. (2009) · Stem Cells · doi:10.1002/stem.281 · Cited by 142 · see citing works
Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation
Tsai, S., Sennett, R., Rezza, A., Clavel, C., Grisanti, L., Zemla, R., Najam, S., & Rendl, M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.11.023 · Cited by 138 · see citing works
Hutton, S. R., & Pevny, L. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.01.015 · Cited by 130 · see citing works
Villeneuve, C., Hashmi, A., Ylivinkka, I., Lawson-Keister, E., Miroshnikova, Y. A., Gonzalez, C. P., Myllymäki, S.-M., Bertillot, F., Yadav, B., Zhang, T., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-023-01332-4 · Cited by 121 · see citing works
Neuropsin (OPN5) Mediates Local Light-Dependent Circadian Responses in Murine Skin
Buhr, E. D., Vemaraju, S., Díaz, N. M., Lang, R. A., & Gelder, R. N. V. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.063 · Cited by 125 · see citing works
Gupta, K., Levinsohn, J. L., Linderman, G. C., Chen, D., Sun, T. Y., Dong, D., Taketo, M. M., Bosenberg, M., Kluger, Y., Choate, K. A., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.11.032 · Cited by 115 · see citing works
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Bardot, E., Valdés, V. J., Zhang, J., Perdigoto, C. N., Nicolis, S. K., Hearn, S., Silva, J. M., & Ezhkova, E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.110 · Cited by 120 · see citing works
Heterogeneity and plasticity of epidermal stem cells
Schepeler, T., Page, M. E., & Jensen, K. B. (2014) · Development · doi:10.1242/dev.104588 · Cited by 120 · see citing works
Self-citationIntestinal Stem Cells and Their Defining Niche
Tan, D. W., & Barker, N. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00003-2 · Cited by 116 · see citing works
Jinno, H., Morozova, O., Jones, K. L., Biernaskie, J., Paris, M., Hosokawa, R., Rudnicki, M. A., Chai, Y., Rossi, F. M. V., Marra, M. A., et al. (2010) · Stem Cells · doi:10.1002/stem.525 · Cited by 116 · see citing works
Mok, K., Saxena, N., Heitman, N., Grisanti, L., Srivastava, D., Muraro, M. J., Jacob, T., Sennett, R., Wang, Z., Su, Y., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.11.034 · Cited by 110 · see citing works
The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles
Li, L., & Ginty, D. D. (2014) · eLife · doi:10.7554/elife.01901 · Cited by 114 · see citing works
Stem Cell Niches for Skin Regeneration
Wong, V., Lévi, B., Rajadas, J., Longaker, M. T., & Gurtner, G. C. (2012) · International Journal of Biomaterials · doi:10.1155/2012/926059 · Cited by 111 · see citing works
Abe, Y., & Tanaka, N. (2017) · Journal of Developmental Biology · doi:10.3390/jdb5040012 · Cited by 105 · see citing works
Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model
Takagi, R., Ishimaru, J., Sugawara, A., Toyoshima, K.-E., Ishida, K., Ogawa, M., Sakakibara, K., Asakawa, K., Kashiwakura, A., Oshima, M., et al. (2016) · Science Advances · doi:10.1126/sciadv.1500887 · Cited by 107 · see citing works
Hu, B., Lefort, K., Qiu, W., Nguyen, B.-C., Rajaram, R. D., Castillo, E., He, F., Chen, Y., Angel, P. E., Brisken, C., et al. (2010) · Genes & Development · doi:10.1101/gad.1886910 · Cited by 106 · see citing works
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models
Griffin, M., Borrelli, M. R., Garcia, J. T., Januszyk, M., King, M. E., Lerbs, T., Cui, L., Moore, A. L., Shen, A. H., Mascharak, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb3312 · Cited by 103 · see citing works
Development and stem cells of the esophagus
Zhang, Y., Jiang, M. Z., Kim, E. S., Lin, S., Liu, K., Lan, X., & Que, J. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.008 · Cited by 100 · see citing works
SOX2 regulates acinar cell development in the salivary gland
Emmerson, E., May, A. J., Nathan, S., Cruz‐Pacheco, N., Lizama, C. O., Maliskova, L., Zovein, A. C., Shen, Y., Muench, M. O., & Knox, S. M. (2017) · eLife · doi:10.7554/elife.26620 · Cited by 99 · see citing works
Mastrogiannaki, M., Lichtenberger, B. M., Reimer, A. S., Collins, C. A., Driskell, R. R., & Watt, F. M. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.01.036 · Cited by 98 · see citing works
Self-citationMethods for the isolation and 3D culture of dermal papilla cells from human hair follicles
Topouzi, H., Logan, N. J., Williams, G., & Higgins, C. A. (2017) · Experimental Dermatology · doi:10.1111/exd.13368 · Cited by 97 · see citing works
Overview of the roles of Sox2 in stem cell and development
Feng, R., & Wen, J. (2015) · Biological Chemistry · doi:10.1515/hsz-2014-0317 · Cited by 97 · see citing works
Fan, S. M., Chang, Y.-T., Chen, C.-L., Wang, W., Pan, M., Chen, W., Huang, W., Xu, Z., Huang, H.-E., Chen, T., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719548115 · Cited by 97 · see citing works
Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods
Taghiabadi, E., Nilforoushzadeh, M. A., & Aghdami, N. (2020) · Skin Pharmacology and Physiology · doi:10.1159/000510152 · Cited by 96 · see citing works
Sox2-Mediated Regulation of Adult Neural Crest Precursors and Skin Repair
Johnston, A. P. W., Naska, S., Jones, K., Jinno, H., Kaplan, D. R., & Miller, F. D. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.04.004 · Cited by 96 · see citing works
Diversification and Specialization of Touch Receptors in SkinPreprint
Owens, D. M., & Lumpkin, E. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013656 · Cited by 94 · see citing works
Biggs, L. C., Mäkelä, O. J., Myllymäki, S.-M., Roy, R. D., Närhi, K. M., Pispa, J., Mustonen, T., & Mikkola, M. L. (2018) · eLife · doi:10.7554/elife.36468 · Cited by 93 · see citing works
Ge, W., Tan, S., Wang, S.-H., Li, L., Sun, X.-F., Shen, W., & Wang, X. (2020) · Theranostics · doi:10.7150/thno.44306 · Cited by 92 · see citing works
Chueh, S., Lin, S., Chen, C., Lei, M., Wang, L. M., Widelitz, R. B., Hughes, M. W., Jiang, T., & Chuong, C. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.739601 · Cited by 91 · see citing works
Skin equivalents: skin from reconstructions as models to study skin development and diseases
Ali, N., Hosseini, M., Vainio, S. J., Taı̈eb, A., Cario, M., & Rezvani, H. R. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13886 · Cited by 90 · see citing works
Besson, V., Smeriglio, P., Wegener, A., Relaix, F., Nait‐Oumesmar, B., Sassoon, D. A., & Marazzi, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103873108 · Cited by 87 · see citing works
Lechner, S. G., & Lewin, G. R. (2013) · Physiology · doi:10.1152/physiol.00059.2012 · Cited by 82 · see citing works
Mistriotis, P., & Andreadis, S. T. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0422 · Cited by 86 · see citing works
Zhu, B., Xu, T., Yuan, J., Guo, X., & Liu, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076282 · Cited by 82 · see citing works
Telerman, S. B., Rognoni, E., Sequeira, I., Pisco, A. O., Lichtenberger, B. M., Culley, O. J., Viswanathan, P., Driskell, R. R., & Watt, F. M. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.06.015 · Cited by 81 · see citing works
Self-citationHair organ regeneration via the bioengineered hair follicular unit transplantation
Asakawa, K., Toyoshima, K.-E., Ishibashi, N., Tobe, H., Iwadate, A., Kanayama, T., Hasegawa, T., Nakao, K., Toki, H., Noguchi, S., et al. (2012) · Scientific Reports · doi:10.1038/srep00424 · Cited by 81 · see citing works
Zhu, H., Shang, D., Sun, M., Choi, S., Liu, Q., Hao, J., Figuera, L. E., Zhang, F., Choy, K. W., Ao, Y., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.004 · Cited by 80 · see citing works
Home sweet home: skin stem cell niches
Goldstein, J., & Horsley, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0943-3 · Cited by 80 · see citing works
Genetic and cellular mechanisms regulating anterior foregut and esophageal development
Jacobs, I. J., Ku, W.-Y., & Que, J. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.016 · Cited by 77 · see citing works
Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea
Atkinson, P. J., Dong, Y., Gu, S., Liu, W., Najarro, E. H., Udagawa, T., & Cheng, A. G.-L. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97248 · Cited by 77 · see citing works
Driskell, R. R., Juneja, V. R., Connelly, J. T., Kretzschmar, K., Tan, D. W., & Watt, F. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.428 · Cited by 76 · see citing works
Self-citationHair follicle stem cells as a skin‐organizing signaling center during adult homeostasis
Li, K. N., & Tumbar, T. (2021) · The EMBO Journal · doi:10.15252/embj.2020107135 · Cited by 75 · see citing works
Modulating hair follicle size with W nt10b/ DKK 1 during hair regeneration
Lei, M., Guo, H., Qiu, W., Lai, X., Yang, T., Widelitz, R. B., Chuong, C., Lian, X., & Yang, L. (2014) · Experimental Dermatology · doi:10.1111/exd.12416 · Cited by 72 · see citing works
Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution in vivo
Miao, Y., Sun, Y., Sun, X., Du, B., Jiang, J.-D., & Hu, Z. (2013) · Dermatologic Surgery · doi:10.1111/dsu.12292 · Cited by 71 · see citing works
Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering
Ohyama, M., & Veraitch, O. K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.02.004 · Cited by 69 · see citing works
Veraitch, O. K., Mabuchi, Y., Matsuzaki, Y., Sasaki, T., Okuno, H., Tsukashima, A., Amagai, M., Okano, H., & Ohyama, M. (2017) · Scientific Reports · doi:10.1038/srep42777 · Cited by 69 · see citing works
β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching
Enshell‐Seijffers, D., Lindon, C., Wu, E., Taketo, M. M., & Morgan, B. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007326107 · Cited by 68 · see citing works
A Single-Cell Transcriptome Atlas of Cashmere Goat Hair Follicle Morphogenesis
Ge, W., Zhang, W., Zhang, Y., Zheng, Y., Li, F., Wang, S., Liu, J., Tan, S., Yan, Z., Wang, L., et al. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2021.07.003 · Cited by 67 · see citing works
The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells
Kretzschmar, K., Cottle, D. L., Schweiger, P. J., & Watt, F. M. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.242 · Cited by 66 · see citing works
Self-citationSox2 modulates the function of two distinct cell lineages in mouse skin
Lesko, M. H., Driskell, R. R., Kretzschmar, K., Goldie, S. J., & Watt, F. M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.08.004 · Cited by 66 · see citing works
Self-citationDerivation of Hair-Inducing Cell from Human Pluripotent Stem Cells
Gnedeva, K., Vorotelyak, E. A., Cimadamore, F., Cattarossi, G., Giusto, E., Terskikh, V. V., & Terskikh, A. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116892 · Cited by 65 · see citing works
- Authors
- Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Cancer Research UK (GB)
- Corresponding author
- Giangreco, Adam
- Watt, Fiona M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2009-08-15
- Volume
- 136
- Issue
- 16
- Pages
- 2815-2823
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC2730408
- OpenAlex
- W2138907299
- Cited by
- 331
- References
- 63
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 15 · 2023: 17 · 2022: 28 · 2021: 17 · 2020: 20 · 2019: 26 · 2018: 18 · 2017: 28 · 2016: 18 · 2015: 21 · 2014: 25 · 2013: 28 · 2012: 26
- FWCI
- 20.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Cancer Research UK
- European Commission (220642)
- Medical Research Council
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- SOX2, dermal papilla cells, CD133, hair follicle development, Wnt signaling, BMP signaling, FGF signaling, Hedgehog signaling, Notch signaling, integrin signaling, neural crest markers
- MeSH terms
- AC133 Antigen, Epidermal Cells, Animals, Embryo, Mammalian, Epidermis, Glycoproteins, Mice, Inbred BALB C, Mice, Nude, Mice, Transgenic, Peptides, Recombinant Fusion Proteins, Signal Transduction, Antigens, CD, Hair Follicle, Dermis, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice, Gene Regulatory Networks, SOXB1 Transcription Factors
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