The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster
Open accessAbstract
Most organisms have evolved defense mechanisms to protect themselves from viruses and other pathogens. Arthropods lack the protein-based adaptive immune response found in vertebrates. Here we show that the central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster. Ago-2-defective flies are hypersensitive to infection with a major fruit fly pathogen, Drosophila C virus (DCV), and with Cricket Paralysis virus (CrPV). Increased mortality in ago-2 mutant flies was associated with a dramatic increase in viral RNA accumulation and virus titers. The physiological significance of this antiviral mechanism is underscored by our finding that DCV encodes a potent suppressor of RNA interference (RNAi). This suppressor binds long double-stranded RNA (dsRNA) and inhibits Dicer-2-mediated processing of dsRNA into short interfering RNA (siRNA), but does not bind short siRNAs or disrupt the microRNA (miRNA) pathway. Based on these results we propose that RNAi is a major antiviral immune defense mechanism in Drosophila.
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Citations
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
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Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
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Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
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Ding, S.-W., & Voinnet, O. (2007) · Cell · doi:10.1016/j.cell.2007.07.039 · Cited by 1,521
Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Waterhouse, R. M., Kriventseva, E. V., Meister, S., Xi, Z., Alvarez, K. S., Bartholomay, L. C., Barillas-Mury, C., Bian, G., Blandin, S., Christensen, B. M., et al. (2007) · Science · doi:10.1126/science.1139862 · Cited by 665
The evolutionary journey of Argonaute proteins
Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J., & van der Oost, J. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2879 · Cited by 543
Metadata
- Authors
- van Rij, R. P., Saleh, M.-C., Berry, B., Foo, C., Houk, A., Antoniewski, C., & Andino, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-11-01
- Volume
- 20
- Issue
- 21
- Pages
- 2985-2995
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2142238693
- Cited by
- 596
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- van Rij, R. P., Saleh, M.-C., Berry, B., Foo, C., Houk, A., Antoniewski, C., & Andino, R. (2006). The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Genes & Development. https://doi.org/10.1101/gad.1482006
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